Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol
Электронный архив ТПУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol
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| Автор |
Rakina, Apollinariya Aleksandrovna
Spiridonova, Tatjyana Igorevna Tverdokhlebov, Sergei Ivanovich |
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| Тематика |
растворение
твердые формы лекарственные формы лекарственные вещества полимерные системы парацетамол биоразлагаемые полимеры |
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| Описание |
Synthetic biodegradable polymers are widely used as materials for the targeted drug delivery and controlled release devices. In order to control the rate of drug release from polymer scaffolds surface ordinary dissolution testing is performed. It includes placing a device into testing media, taking probes at determined time and estimating the drug concentration. As for prolonged release the issue is the drug degradation in test media what leads to false interpretation of results. This study was focused on the investigation of paracetamol degradation in phosphate buffer saline media for three days and its effect on the results of polymeric drug delivery system dissolution test. It was shown, that relative error in the released drug concentration evaluation can rise up to 34% depending on the exposure time and the initial probe concentration. An approach of experimental results correction is proposed.
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| Дата |
2019-08-06T07:10:08Z
2019-08-06T07:10:08Z 2019 |
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| Тип |
Conference Paper
Published version (info:eu-repo/semantics/publishedVersion) Conference paper (info:eu-repo/semantics/conferencePaper) |
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| Идентификатор |
Rakina A. A. Dissolution testing for prolonged-release solid dosage form containing drug substances degrading in test media. Application to polymeric delivery systems of paracetamol / A. A. Rakina, T. I. Spiridonova, S. I. Tverdokhlebov // IOP Conference Series: Materials Science and Engineering. — Bristol : IOP Publishing, 2019. — Vol. 511 : Perspective Materials of Constructional and Medical Purpose : International Scientific and Technical Youth Conference, 26–30 November 2018, Tomsk, Russian Federation : [proceedings]. — [012007, 6 p.].
http://earchive.tpu.ru/handle/11683/55439 10.1088/1757-899X/511/1/012007 |
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| Язык |
en
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| Связанные ресурсы |
IOP Conference Series: Materials Science and Engineering. Vol. 511 : Perspective Materials of Constructional and Medical Purpose. — Bristol, 2019.
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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IOP Publishing
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