Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
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| Автор |
Khizrieva, S. S.
Vetrova, E. V. Borisenko, S. N. Maksimenko, E. V.; Borisenko, N. I. |
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| Тематика |
CAMPHECENE
QUERCETIN RUTIN ANTIVIRAL ACTIVITY SUPRAMOLECULAR COMPLEXES |
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| Описание |
Received: 01.03.2021. Revised: 22.04.2021. Accepted: 27.04.2021. Available online: 28.04.2021.
The authors are grateful to the Corresponding Member of the RAS, Doctor of Chemical Sciences, Professor of NIOCH SB RAS Salakhutdinov N.F. for the kindly provided scaffold monoterpenoid Camphecene. Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation of the host: guest complexes were registered: Qu and Rut molecular complexes (Camph+2Qu; Camph+2Rut) with a stability constant K = 3.3·108 M-2. Comparison of the binding constants of the obtained complexes shows that the efficiency of Camphecene complexation with the participation of flavonoids is more efficient than with the participation of triterpenoids. Besides, it was found that the complexes of Camphecene with the quercetin and rutin are soluble in water, in contrast to the complexes with triterpenoids, which makes it possible to increase the bioavailability of both Camphecene and flavonoids. The obtained results demonstrate the high potential of flavonoids Qu and Rut to the development of novel pharmaceutical forms using the example of Camphecene in the form of molecular complexes, as the novel forms of delivery. This work was supported by the Ministry of Science and Higher Education of the Russian Federation (State assignment in the field of scientific activity, project No 0852-2020-0031) and the Russian Foundation for Basic Research (RFBR, grant no. 19-33-90211-Aspiranty). |
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| Дата |
2021-08-09T10:21:14Z
2021-08-09T10:21:14Z 2021-07 |
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Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Khizrieva S. S. Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids / S. S. Khizrieva , E. V. Vetrova, S. N. Borisenko, E. V. Maksimenko, N. I. Borisenko // Chimica Techno Acta. — 2021. — Vol. 8, No. 2. — № 20218202.
2411-1414 http://elar.urfu.ru/handle/10995/100699 https://www.elibrary.ru/item.asp?id=46407564 |
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| Язык |
en
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| Связанные ресурсы |
Chimica Techno Acta. 2021. Vol. 8. № 2
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| Формат |
application/pdf
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Ural Federal University
Уральский федеральный университет |
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