Improvement of Biocompatibility of High Molecular Weight Poly-3-hydroxybutyrate by Blending with its Functionalized Oligomers
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Improvement of Biocompatibility of High Molecular Weight Poly-3-hydroxybutyrate by Blending with its Functionalized Oligomers
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| Автор |
Boyandin, A. N.
Dvoinina, L. M. Sukovatyi, A. G. Sukhanova, A. A. Ertiletskaya, N. L. |
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| Тематика |
BIOCOMPATIBLE ATERIALS
POLY-3-HYDROXYBUTYRATE FUNCTIONALIZED LIGOMERS AMINOLYSIS POLYMER-OLIGOMER LENDS BIOCOMPATIBILITY |
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| Описание |
Received: 22.11.23. Revised: 22.12.23. Accepted: 26.12.23. Available online: 16.01.24.
Addition of aminated oligomers of poly-3-hydroxybutyrate (PHB) to the parent PHB improves the hydrophilicity of the obtained blends. The biocompatibility of the obtained polymer-oligomer films was demonstrated via an increased adhesion of NIH-3T3 mouse fibroblasts. Only moderate influence of the oligomer presence of the mechanical properties of the polymer-oligomer blends was observed. Oligomers of poly-3-hydroxybutyrate (PHB) were prepared by aminolysis of high molecular weight PHB with ethylenediamine and 1,4-diaminobutane. Polymer-oligomer blends (10, 30, and 50% content of the oligomers) were prepared as films by solution casting. As the content of oligomers increased, a gradual increase in the hydrophilicity of the polymer surface was observed, resulting reflected in the water contact angle decrease from 84° to 72–76°. In addition, a moderate decrease in elongation at break, Young's modulus, and tensile strength for the blends were observed as more oligomer was added to the film. Finally, the viability of NIH-3T3 mouse fibroblasts was higher compared to intact PHB when growing in non-prepared polymer/oligomer mixtures. These findings confirm the benefits of the introduction of a hydrophilic functionalized oligomer into the PHB matrix in terms of improving the biocompatibility of the resulting polymer/oligomer blends. This work was carried out within the state assignment of the Ministry of Science and Higher Education of the Russian Federation for the implementation of the project “Development of multifunctional smart materials and structures based on modified polymer composite materials capable to function in extreme conditions” (No FEFE-2020-0015). |
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| Дата |
2024-04-02T12:36:08Z
2024-04-02T12:36:08Z 2024 |
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| Тип |
Article
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| Идентификатор |
Improvement of Biocompatibility of High Molecular Weight Poly-3-hydroxybutyrate by Blending with its Functionalized Oligomers / A. N. Boyandin, L. M. Dvoinina, A. G. Sukovatyi, A. A. Sukhanova, N. L. Ertiletskaya // Chimica Techno Acta. — 2024. — Vol. 11, No. 1. — No. 202411101.
2411-1414 http://elar.urfu.ru/handle/10995/130137 https://elibrary.ru/item.asp?id=65118500 10.15826/chimtech.2024.11.1.01 |
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| Язык |
en
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| Связанные ресурсы |
Chimica Techno Acta. 2024. Vol. 11. № 1
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| Издатель |
Уральский федеральный университет
Ural Federal University |
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