Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action
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| Автор |
Sharapov, A. D.
Fatykhov, R. F. Khalymbadzha, I. A. Zyryanov, G. V. Chupakhin, O. N. Tsurkan, M. V. |
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| Тематика |
ANTI-HIV AGENTS
COUMARINS FUROCOUMARINS INTEGRASE INHIBITORS NATURAL PRODUCTS PYRANOCOUMARINS REVERSE TRANSCRIPTASE INHIBITORS CALANOLIDE A COUMARIN DERIVATIVE DITERPENOID FUROCOUMARIN DERIVATIVE MONOTERPENOID PYRANOCOUMARIN DERIVATIVE TERPENOID WEDELOLACTONE ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT ANTIVIRUS AGENT COUMARIN DERIVATIVE PYRANOCOUMARIN DERIVATIVE RNA DIRECTED DNA POLYMERASE RNA DIRECTED DNA POLYMERASE INHIBITOR ANTIINFLAMMATORY ACTIVITY ANTIVIRAL ACTIVITY BIOLOGICAL ACTIVITY BIOSYNTHESIS DRUG ISOLATION DRUG MECHANISM DRUG STRUCTURE DRUG TARGETING EC50 HUMAN HUMAN IMMUNODEFICIENCY VIRUS 1 HYDROGEN BOND IC50 NONHUMAN REVIEW STRUCTURE ACTIVITY RELATION THERAPEUTIC INDEX TRANSACTIVATION VIRUS PARTICLE VIRUS REPLICATION HUMAN IMMUNODEFICIENCY VIRUS 1 ANTI-HIV AGENTS ANTIVIRAL AGENTS COUMARINS HIV REVERSE TRANSCRIPTASE HIV-1 PYRANOCOUMARINS REVERSE TRANSCRIPTASE INHIBITORS |
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| Описание |
This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action. This review summarizes the information on the anti-HIV properties of simple coumarins as well as annulated furano- and pyranocoumarins and shows that coumarins of plant origin can act by several mechanisms: inhibition of HIV reverse transcriptase and integrase, inhibition of cellular factors that regulate HIV-1 replication, and transmission of viral particles from infected macrophages to healthy ones. It is important to note that some pyranocoumarins are able to act through several mechanisms or bind to several sites, which ensures the resistance of these compounds to HIV mutations. Here we review the last two decades of research on the anti-HIV activity of naturally occurring coumarins. © 2023 by the authors.
Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-1118; Russian Science Foundation, RSF: 21-13-00382 This research was funded by the Ministry of Science and Higher Education of the Russian Federation grant 075-15-2022-1118 (Section “Simple coumarins”) and the Russian Science Foundation, grant number 21-13-00382 (Sections “Furocoumarins” and “Pyranocoumarins”). |
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| Дата |
2024-04-05T16:15:29Z
2024-04-05T16:15:29Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Sharapov, AD, Fatykhov, RF, Khalymbadzha, IA, Zyryanov, GV, Chupakhin, ON & Tsurkan, MV 2023, 'Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action', International Journal of Molecular Sciences, Том. 24, № 3, 2839. https://doi.org/10.3390/ijms24032839
Sharapov, A. D., Fatykhov, R. F., Khalymbadzha, I. A., Zyryanov, G. V., Chupakhin, O. N., & Tsurkan, M. V. (2023). Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action. International Journal of Molecular Sciences, 24(3), [2839]. https://doi.org/10.3390/ijms24032839 1661-6596 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147895066&doi=10.3390%2fijms24032839&partnerID=40&md5=8315130f3681703355eb0ed8d64dfcf5 https://www.mdpi.com/1422-0067/24/3/2839/pdf?version=1675310372 http://elar.urfu.ru/handle/10995/130199 10.3390/ijms24032839 85147895066 000932571000001 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//21-13-00382
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
International Journal of Molecular Sciences
International Journal of Molecular Sciences |
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