Mathematical Modelling of Leptin-Induced Effects on Electrophysiological Properties of Rat Cardiomyocytes and Cardiac Arrhythmias
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Mathematical Modelling of Leptin-Induced Effects on Electrophysiological Properties of Rat Cardiomyocytes and Cardiac Arrhythmias
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| Автор |
Nesterova, T.
Rokeakh, R. Solovyova, O. Panfilov, A. |
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| Тематика |
CARDIAC ARRHYTHMIA
CARDIAC MODELING HYPERLEPTINEMIA LEPTIN RAT VENTRICULAR CARDIOMYOCYTES RAT VENTRICULAR TISSUE |
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| Описание |
Elevated plasma leptin levels, or hyperleptinemia, have been demonstrated to correlate with metabolic syndrome markers, including obesity, and may be an independent risk factor for the development of cardiovascular disease. In this paper, we use cardiac models to study possible effects of hyperleptinemia on the electrophysiological properties of cardiomyocytes and cardiac arrhythmias. We modified the parameters of an improved Gattoni 2016 model of rat ventricular cardiomyocytes to simulate experimental data for the leptin effects on ionic currents. We used four model variants to investigate the effects of leptin-induced parameter modification at the cellular level and in 2D tissue. In all models, leptin was found to increase the duration of the action potential. In some cases, we observed a dramatic change in the shape of the action potential from triangular, characteristic of rat cardiomyocytes, to a spike-and-dome, indicating predisposition to arrhythmias. In all 2D tissue models, leptin increased the period of cardiac arrhythmia caused by a spiral wave and enhanced dynamic instability, manifesting as increased meandering, onset of hypermeandering, and even spiral wave breakup. The leptin-modified cellular models developed can be used in subsequent research in rat heart anatomy models. © 2023 by the authors.
Ministry of Education and Science of the Russian Federation, Minobrnauka The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged. |
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| Дата |
2024-04-05T16:16:24Z
2024-04-05T16:16:24Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Nesterova, T, Rokeakh, R, Solovyova, O & Panfilov, A 2023, 'Mathematical Modelling of Leptin-Induced Effects on Electrophysiological Properties of Rat Cardiomyocytes and Cardiac Arrhythmias', Mathematics, Том. 11, № 4, 874. https://doi.org/10.3390/math11040874
Nesterova, T., Rokeakh, R., Solovyova, O., & Panfilov, A. (2023). Mathematical Modelling of Leptin-Induced Effects on Electrophysiological Properties of Rat Cardiomyocytes and Cardiac Arrhythmias. Mathematics, 11(4), [874]. https://doi.org/10.3390/math11040874 2227-7390 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149002052&doi=10.3390%2fmath11040874&partnerID=40&md5=98f41f622beacccf3346885a58255d75 https://www.mdpi.com/2227-7390/11/4/874/pdf?version=1676023367 http://elar.urfu.ru/handle/10995/130233 10.3390/math11040874 85149002052 000940830400001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Mathematics
Mathematics |
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