Просмотреть запись

Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles

Электронный научный архив УРФУ

Информация об архиве | Просмотр оригинала
 
 
Поле Значение
 
Заглавие Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles
 
Автор Minigalieva, I. A.
Ryabova, Y. V.
Shelomencev, I. G.
Amromin, L. A.
Minigalieva, R. F.
Sutunkova, Y. M.
Privalova, L. I.
Sutunkova, M. P.
 
Тематика ELECTRON MICROSCOPY
KINETICS OF NANOPARTICLES
NEUROTOXICITY
IRON OXIDE NANOPARTICLE
FERRIC ION
NANOPARTICLE
ABNORMAL ANIMAL BEHAVIOR
ANIMAL EXPERIMENT
ANIMAL TISSUE
ARTICLE
AXONAL INJURY
BASAL GANGLION
BEHAVIOR DISORDER
BLOOD
BRAIN FUNCTION
BRAIN INJURY
BRAIN MITOCHONDRION
BRAIN TISSUE
CENTRAL NERVOUS SYSTEM
CONTROLLED STUDY
DATA ANALYSIS
DEMYELINATION
ELECTRON MICROSCOPY
EXPERIMENTAL STUDY
EXPLORATORY BEHAVIOR
FEMALE
HOLE BOARD TEST
MITOCHONDRIAL TOXICITY
MYELIN SHEATH
NANOTOXICOLOGY
NEUROPATHOLOGY
NEUROTOXICITY
NONHUMAN
OLFACTORY BULB
RAT
ULTRASTRUCTURE
ANIMAL
BRAIN
CHEMISTRY
INTRANASAL DRUG ADMINISTRATION
METABOLISM
MITOCHONDRION
ADMINISTRATION, INTRANASAL
ANIMALS
BASAL GANGLIA
BRAIN
FERRIC COMPOUNDS
MITOCHONDRIA
NANOPARTICLES
RATS
 
Описание Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but not in the basal ganglia of the brain after their subchronic intranasal administration. We observed an increase in the number of axons with damaged myelin sheaths and in the proportion of pathologically altered mitochondria in the brains of the exposed animals against the background of almost stable blood parameters. We conclude that the central nervous system can be a target for toxicity of low-dose exposure to Fe2O3 nanoparticles. © 2023 by the authors.
Ministry of Education and Science of the Russian Federation, Minobrnauka; Ural Federal University, UrFU
The analysis was supported by the Ministry of Science and Higher Education of the Russian Federation within the “Priority—2030” Development Program of the Ural Federal University; the experimental data were provided by Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers.
 
Дата 2024-04-05T16:16:30Z
2024-04-05T16:16:30Z
2023
 
Тип Article
Journal article (info:eu-repo/semantics/article)
|info:eu-repo/semantics/publishedVersion
 
Идентификатор Minigalieva, IA, Ryabova, YV, Shelomencev, IG, Amromin, LA, Minigalieva, RF, Sutunkova, YM, Privalova, LI & Sutunkova, MP 2023, 'Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles', International Journal of Molecular Sciences, Том. 24, № 4, 3572. https://doi.org/10.3390/ijms24043572
Minigalieva, I. A., Ryabova, Y. V., Shelomencev, I. G., Amromin, L. A., Minigalieva, R. F., Sutunkova, Y. M., Privalova, L. I., & Sutunkova, M. P. (2023). Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles. International Journal of Molecular Sciences, 24(4), [3572]. https://doi.org/10.3390/ijms24043572
1661-6596
Final
All Open Access, Gold, Green
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149053000&doi=10.3390%2fijms24043572&partnerID=40&md5=c0c82763c119fdc24cfed04d9b549a0a
https://www.mdpi.com/1422-0067/24/4/3572/pdf?version=1676020978
http://elar.urfu.ru/handle/10995/130238
10.3390/ijms24043572
85149053000
000939322400001
 
Язык en
 
Права Open access (info:eu-repo/semantics/openAccess)
cc-by
https://creativecommons.org/licenses/by/4.0/
 
Формат application/pdf
 
Издатель MDPI
 
Источник International Journal of Molecular Sciences
International Journal of Molecular Sciences