Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models
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| Автор |
Kotova, M. M.
Galstyan, D. S. Kolesnikova, T. O. de, Abreu, M. S. Amstislavskaya, T. G. Strekalova, T. Petersen, E. V. Yenkoyan, K. B. Demin, K. A. Kalueff, A. V. |
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| Тематика |
ANTIBIOTIC
ANTIMICROBIAL DRUGS BEHAVIOR BRAIN MICROBIOTA ZEBRAFISH 1,3 DIKETONE AMINOGLYCOSIDE ANTIBIOTIC AGENT ANTIBIOTIC AGENT ANTIINFECTIVE AGENT CEPHALOSPORIN DERIVATIVE LINCOSAMIDE NONSTEROID ANTIINFLAMMATORY AGENT PENICILLIN DERIVATIVE PHENOL DERIVATIVE SECOIRIDOID SULFONAMIDE ANIMAL BEHAVIOR ANTIMICROBIAL ACTIVITY BRAIN-GUT AXIS CELL LEVEL CENTRAL NERVOUS SYSTEM CLINICAL SIGNIFICANCE DRUG EFFECT DRUG EFFICACY IN VIVO STUDY INTESTINE FLORA NONHUMAN REVIEW RODENT ZEBRA FISH |
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| Описание |
Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut–microbiota–brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish (Danio rerio) emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism. © 2023 by the authors.
075-15-2021-684, 857600; Saint Petersburg State University, SPbU: 93020614; Suzhou University of Science and Technology: NRB-RND-2116; State Committee of Science, SCS: 20TTCG-3A012, N10-14/I-1 A.V.K. is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this collaborative multi-laboratory project jointly with COBRAIN Center (headed by K.B.Y.) supported by the Republic of Armenia State Committee of Science (20TTCG-3A012 and N10-14/I-1) and the European Union-funded H2020 COBRAIN project (857600). The consortium provided a collaborative idea exchange platform for this study, and did not fund the study. The study partially used the facilities and equipment of the Resource Fund of Applied Genetics, MIPT support grant 075-15-2021-684. This work was supported by St. Petersburg State University (project ID 93020614). T.O.K. is supported by Sirius University of Science and Technology (project NRB-RND-2116). The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish. |
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| Дата |
2024-04-05T16:16:49Z
2024-04-05T16:16:49Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Kotova, MM, Galstyan, DS, Kolesnikova, TO, De Abreu, MS, Amstislavskaya, TG, Strekalova, T, Petersen, EV, Yenkoyan, KB, Demin, KA & Kalueff, AV 2023, 'Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models', Veterinary Sciences, Том. 10, № 2, 96. https://doi.org/10.3390/vetsci10020096
Kotova, M. M., Galstyan, D. S., Kolesnikova, T. O., De Abreu, M. S., Amstislavskaya, T. G., Strekalova, T., Petersen, E. V., Yenkoyan, K. B., Demin, K. A., & Kalueff, A. V. (2023). Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models. Veterinary Sciences, 10(2), [96]. https://doi.org/10.3390/vetsci10020096 2306-7381 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149201751&doi=10.3390%2fvetsci10020096&partnerID=40&md5=e898b9378f1ab79e501c63351439a9c8 https://www.mdpi.com/2306-7381/10/2/96/pdf?version=1674961343 http://elar.urfu.ru/handle/10995/130246 10.3390/vetsci10020096 85149201751 000942370800001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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MDPI
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| Источник |
Veterinary Sciences
Veterinary Sciences |
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