Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy
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| Автор |
Shevlyakov, A. D.
Kolesnikova, T. O. de, Abreu, M. S. Petersen, E. V. Yenkoyan, K. B. Demin, K. A. Kalueff, A. V. |
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| Тематика |
EPILEPSY
GENES GENETIC BASES IN SILICO MODELING MOLECULAR NETWORK ANTICONVULSIVE AGENT MAMMALIAN TARGET OF RAPAMYCIN TRANSCRIPTION FACTOR ANTICONVULSANT THERAPY CELL DIVISION CHROMATIN ASSEMBLY AND DISASSEMBLY COMPUTER MODEL CYTOSKELETON EPILEPSY EPILEPTOGENESIS GENETIC ASSOCIATION HEREDITY HUMAN METABOLISM MITOCHONDRIAL BIOGENESIS MITOCHONDRION MOLECULAR PATHOLOGY MTOR SIGNALING NONHUMAN REVIEW SIGNAL TRANSDUCTION SYSTEMS BIOLOGY EPILEPSY GENOME SEIZURE ANTICONVULSANTS EPILEPSY GENOME HUMANS SEIZURES SYSTEMS BIOLOGY |
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| Описание |
Epilepsy is a highly prevalent, severely debilitating neurological disorder characterized by seizures and neuronal hyperactivity due to an imbalanced neurotransmission. As genetic factors play a key role in epilepsy and its treatment, various genetic and genomic technologies continue to dissect the genetic causes of this disorder. However, the exact pathogenesis of epilepsy is not fully understood, necessitating further translational studies of this condition. Here, we applied a computational in silico approach to generate a comprehensive network of molecular pathways involved in epilepsy, based on known human candidate epilepsy genes and their established molecular interactors. Clustering the resulting network identified potential key interactors that may contribute to the development of epilepsy, and revealed functional molecular pathways associated with this disorder, including those related to neuronal hyperactivity, cytoskeletal and mitochondrial function, and metabolism. While traditional antiepileptic drugs often target single mechanisms associated with epilepsy, recent studies suggest targeting downstream pathways as an alternative efficient strategy. However, many potential downstream pathways have not yet been considered as promising targets for antiepileptic treatment. Our study calls for further research into the complexity of molecular mechanisms underlying epilepsy, aiming to develop more effective treatments targeting novel putative downstream pathways of this disorder. © 2023 by the authors.
075-15-2021-684; 857600; Saint Petersburg State University, SPbU: 93020614; Suzhou University of Science and Technology: NRB-RND-2116; State Committee of Science, SCS: 20TTCG-3A012, N10-14/I-1 The study was performed in collaboration with the YSMU COBRAIN Scientific-Educational Center for Fundamental Brain Research, supported by the Republic of Armenia State Committee of Science (20TTCG-3A012 and N10-14/I-1) and the European Union-funded H2020 COBRAIN project (857600). The research was supported by Sirius University of Science and Technology Project ID NRB-RND-2116. K.A.D. was supported by St. Petersburg State University state budgetary funds (Project ID 93020614). The study partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). |
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| Дата |
2024-04-05T16:18:13Z
2024-04-05T16:18:13Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Shevlyakov, AD, Kolesnikova, TO, De abreu, MS, Petersen, EV, Yenkoyan, KB, Demin, KA & Kalueff, AV 2023, 'Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy', International Journal of Molecular Sciences, Том. 24, № 6, 5280. https://doi.org/10.3390/ijms24065280
Shevlyakov, A. D., Kolesnikova, T. O., De abreu, M. S., Petersen, E. V., Yenkoyan, K. B., Demin, K. A., & Kalueff, A. V. (2023). Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy. International Journal of Molecular Sciences, 24(6), [5280]. https://doi.org/10.3390/ijms24065280 1661-6596 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151110646&doi=10.3390%2fijms24065280&partnerID=40&md5=b63d8cabfee383f0de94f412769b4006 https://www.mdpi.com/1422-0067/24/6/5280/pdf?version=1678370078 http://elar.urfu.ru/handle/10995/130306 10.3390/ijms24065280 85151110646 000959151300001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
International Journal of Molecular Sciences
International Journal of Molecular Sciences |
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