An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
An Isothiazolanthrone-Based Self-Assembling Anticancer Color-Changing Dye for Concurrent Imaging and Monitoring of Cell Viability
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| Автор |
Gour, N.
Kshtriya, V. Khatun, S. Bandyopadhyay, S. Ghosh, R. Koshti, B. Singh, R. Haque, A. Bhatia, D. Joshi, K. B. Boukhvalov, D. W. Nath, S. Rengan, A. K. |
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| Тематика |
ANTICANCER PROPERTIES
CELL IMAGING CHARGE TRANSFER COMPUTATIONAL MODELING FLUORESCENT DYE SELF-ASSEMBLY CELL CULTURE CELLS COMPUTATION THEORY COMPUTERIZED TOMOGRAPHY FLUORESCENCE SELF ASSEMBLY ANTICANCER PROPERTIES BIOLOGICAL EVALUATION CELL IMAGING CELL VIABILITY COLOR CHANGING COMPUTATIONAL MODELLING FLUORESCENT DYES PHOTOPHYSICAL PROPERTIES PHOTOPHYSICAL STUDIES SELF-ASSEMBLING CHARGE TRANSFER SOLVENT ANIMAL CELL LINE CELL SURVIVAL MOUSE PROCEDURES SPECTROFLUOROMETRY ANIMALS CELL LINE CELL SURVIVAL MICE SOLVENTS SPECTROMETRY, FLUORESCENCE |
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| Описание |
We report the photophysical properties, self-assembly and biological evaluation of an isothiazolanthrone-based dye, 7-amino-6H-anthra[9,1-cd]isothiazol-6-one (AAT), which reveals anticancer properties and can be potentially used as dye for monitoring cell viability. The solvent-dependent photophysical studies suggest that the emission of AAT is sensitive to environment polarity due to which interesting changes in the colored emission may be observed owing to the charge transfer (CT) processes. AAT also self-assembles to tree-like branched morphologies and produce, a greenish emission inside the cells when imaged after short interval (15 mins) of incubation while a red fluorescence could be noted after 24 h. Interestingly, AAT also produce differential emission inside mouse normal cells as compared to its cancer cell lines since it possess anticancer activity. The experimental observations were also validated theoretically via computational modeling. © 2023 Wiley-VCH GmbH.
Indian Council of Medical Research, ICMR: 45/13/2020‐/BIO/BMS; Science and Engineering Research Board, SERB: EMR/2016/003186, SPG/2021/000521; Ministry of Education and Science of the Russian Federation, Minobrnauka: FEUZ‐2023‐0013 NG, greatly acknowledge support from the SERB research grants (EMR/2016/003186; SPG/2021/000521) for funding. VK is grateful to ICMR, India for providing financial support under the Senior Research Fellowship No. 45/13/2020‐/BIO/BMS. BK thanks SHODH fellowship for funding and Indrashil University for infrastructure support. RS thanks CSIR‐UGC for the pre‐doctoral senior research fellowship. KBJ acknowledges Sophisticated Instrument Centre (SIC)‐Dr. Harisingh Gour Central University Sagar, India for AFM facility. DWB acknowledged support Ministry of Science and Higher Education of the Russian Federation (through the basic part of the government mandate, Project No. FEUZ‐2023‐0013) and Jiangsu Innovative and Entrepreneurial Talents Project. NG thanks Dr. Abhijit Patra, Mr. Subhadeep Das and Mr. Subhankar Kundu, IISER Bhopal, for TCSPC sample analysis and quntum yield measurement using solid state fluorescence.. NG, greatly acknowledge support from the SERB research grants (EMR/2016/003186; SPG/2021/000521) for funding. VK is grateful to ICMR, India for providing financial support under the Senior Research Fellowship No. 45/13/2020-/BIO/BMS. BK thanks SHODH fellowship for funding and Indrashil University for infrastructure support. RS thanks CSIR-UGC for the pre-doctoral senior research fellowship. KBJ acknowledges Sophisticated Instrument Centre (SIC)-Dr. Harisingh Gour Central University Sagar, India for AFM facility. DWB acknowledged support Ministry of Science and Higher Education of the Russian Federation (through the basic part of the government mandate, Project No. FEUZ-2023-0013) and Jiangsu Innovative and Entrepreneurial Talents Project. NG thanks Dr. Abhijit Patra, Mr. Subhadeep Das and Mr. Subhankar Kundu, IISER Bhopal, for TCSPC sample analysis and quntum yield measurement using solid state fluorescence. |
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| Дата |
2024-04-05T16:18:53Z
2024-04-05T16:18:53Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/submittedVersion |
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| Идентификатор |
Gour, N, Kshtriya, V, Khatun, S, Bandyopadhyay, S, Ghosh, R, Koshti, B, Singh, R, Haque, A, Bhatia, D, Joshi, KB, Boukhvalov, DW, Nath, S & Rengan, AK 2023, 'An Isothiazolanthrone‐Based Self‐Assembling Anticancer Color‐Changing Dye for Concurrent Imaging and Monitoring of Cell Viability', Chemistry - An Asian Journal, Том. 18, № 9, e202300044. https://doi.org/10.1002/asia.202300044
Gour, N., Kshtriya, V., Khatun, S., Bandyopadhyay, S., Ghosh, R., Koshti, B., Singh, R., Haque, A., Bhatia, D., Joshi, K. B., Boukhvalov, D. W., Nath, S., & Rengan, A. K. (2023). An Isothiazolanthrone‐Based Self‐Assembling Anticancer Color‐Changing Dye for Concurrent Imaging and Monitoring of Cell Viability. Chemistry - An Asian Journal, 18(9), [e202300044]. https://doi.org/10.1002/asia.202300044 1861-4728 Final All Open Access, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151455872&doi=10.1002%2fasia.202300044&partnerID=40&md5=d82c9296a0a8534ce2c01e42b6b155aa https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c755ad567dfe0f83ec6324/original/self-assembly-and-photophysical-studies-of-an-unusual-red-colored-dye-which-show-green-fluorescence-in-cell-imaging.pdf http://elar.urfu.ru/handle/10995/130362 10.1002/asia.202300044 85151455872 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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| Формат |
application/pdf
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| Издатель |
John Wiley and Sons Ltd
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| Источник |
Chemistry – An Asian Journal
Chemistry - An Asian Journal |
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