Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats
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| Автор |
Ashry, M.
Askar, H. Obiedallah, M. M. Elankily, A. H. Galal, El-Sahra, D. Zayed, G. Mustafa, M. A. El-Shamy, S. A. E. -M. Negm, S. A. El-Beltagy, M. A. Abdel-Wahhab, K. G. Ene, A. |
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| Тематика |
ANTI-INFLAMMATORY
HESPERIDIN HYPERTHYROIDISM L-THYROXINE RAT ANTIOXIDANT ASPARTATE AMINOTRANSFERASE CALCITONIN CATALASE CD4 ANTIGEN CREATININE GLUTATHIONE GLUTATHIONE PEROXIDASE HESPERIDIN HIGH DENSITY LIPOPROTEIN CHOLESTEROL INTERLEUKIN 10 INTERLEUKIN 1BETA INTERLEUKIN 4 INTERLEUKIN 6 LEVOTHYROXINE LOW DENSITY LIPOPROTEIN CHOLESTEROL MALONALDEHYDE SUPEROXIDE DISMUTASE THYROTROPIN THYROXINE TRIACYLGLYCEROL TUMOR NECROSIS FACTOR UREA ANTIOXIDANT HESPERIDIN ADULT ANIMAL EXPERIMENT ANIMAL MODEL ANTIOXIDANT ACTIVITY ANTIOXIDANT ASSAY ARTICLE ATHEROSCLEROSIS CONTROLLED STUDY FEMALE HISTOLOGY HISTOPATHOLOGY HYPERTHYROIDISM IMMUNOHISTOCHEMISTRY NONHUMAN OXIDATIVE STRESS RAT THYROID FOLLICLE THYROID GLAND THYROXINE BLOOD LEVEL UPREGULATION ANIMAL METABOLISM ANIMALS ANTIOXIDANTS FEMALE HESPERIDIN HYPERTHYROIDISM OXIDATIVE STRESS SUPEROXIDE DISMUTASE |
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| Описание |
The goal of the current study was to investigate the hormonal modulatory efficiency of hesperidin, through its regulatory potential of immunological, inflammatory, and/or antioxidant changes in on hyperthyroidism modeled adult female albino rats. Both normal and hyperthyroidism modeled rats (140-160g) were randomly divided into four groups (10 animals each) as follows: 1) healthy animals were daily ingested with saline for six weeks, and served as control group, 2) healthy animals were intraperitoneally injected with hesperidin (50 mg/kg/day) for a similar period, 3) hyperthyroidism-modeled animals without any treatment acted as positive control, and 4) hyperthyroidism-modeled animals were treated intraperitoneally with hesperidin for a similar period. The findings showed that hesperidin significantly modulated hyperthyroidism deteriorations, this was evidenced by a remarkable decline in serum T4, FT4, T3, FT3, TNF-α, IL1β-, IL4-, IL-6, and IL-10 levels, with a minor increase in TSH and significant raise in CD4+ level. Similarly, valuable improvement was observed in the oxidative status; serum SOD, GPx, CAT, and GSH levels were dramatically enhanced, associated with remarkable drop in MDA and NO levels. Also, hesperidin demonstrated nephro-hepatoprotective and anti-atherogenic potential, this was achieved from the notable reduction in ALAT and ASAT activities as well as urea, creatinine, cholesterol, and triglyceride close to the corresponding values of healthy group. These findings were supported by histological and immunohistochemical ones that showed a notable decrease in the expression of the calcitonin antibody. In conclusion, hesperidin possesses anti-hyperthyroidism, immunoinflammatory regulatory, and antioxidant activities that evidenced from the improvement of physio-architecture of the thyroid gland, reduction of inflammation and restoration of the impaired oxidative stress. This effect might be mechanized through immunological, inflammatory, apoptotic, and/or antioxidant modulatory pathways. Copyright © 2023 Ashry, Askar, Obiedallah, Elankily, Galal El-Sahra, Zayed, Mustafa, El-Shamy, Negm, El-Beltagy, Abdel-Wahhab and Ene.
Universitatea 'Dunărea de Jos' Galați, UDJG The work of author A.E. and APC were financed by Dunarea de Jos University of Galati, Romania. |
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| Дата |
2024-04-05T16:19:02Z
2024-04-05T16:19:02Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Ashry, M, Askar, H, Obiedallah, MM, Elankily, AH, Galal el-Sahra, D, Zayed, G, Mustafa, MA, El-Shamy, SAE, Negm, SA, El-Beltagy, MA, Abdel-Wahhab, KG & Ene, A 2023, 'Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats', Frontiers in Immunology, Том. 14, 1087397. https://doi.org/10.3389/fimmu.2023.1087397
Ashry, M., Askar, H., Obiedallah, M. M., Elankily, A. H., Galal el-Sahra, D., Zayed, G., Mustafa, M. A., El-Shamy, S. A. E., Negm, S. A., El-Beltagy, M. A., Abdel-Wahhab, K. G., & Ene, A. (2023). Hormonal and inflammatory modulatory effects of hesperidin in hyperthyroidism-modeled rats. Frontiers in Immunology, 14, [1087397]. https://doi.org/10.3389/fimmu.2023.1087397 1664-3224 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151792410&doi=10.3389%2ffimmu.2023.1087397&partnerID=40&md5=4501567da0b753bdabb276b477587a2d https://www.frontiersin.org/articles/10.3389/fimmu.2023.1087397/pdf http://elar.urfu.ru/handle/10995/130371 10.3389/fimmu.2023.1087397 85151792410 000961369200001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Frontiers Media S.A.
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| Источник |
Frontiers in Immunology
Frontiers in Immunology |
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