Просмотреть запись

ANTIVIRAL PROPERTIES OF VERDAZYLS AND LEUCOVERDAZYLS AND THEIR ACTIVITY AGAINST GROUP B ENTEROVIRUSES

Электронный научный архив УРФУ

Информация об архиве | Просмотр оригинала
 
 
Поле Значение
 
Заглавие ANTIVIRAL PROPERTIES OF VERDAZYLS AND LEUCOVERDAZYLS AND THEIR ACTIVITY AGAINST GROUP B ENTEROVIRUSES
 
Автор Volobueva, A. S.
Zarubaev, V. V.
Fedorchenko, T. G.
Lipunova, G. N.
Tungusov, V. N.
Chupakhin, O. N.
 
Тематика ANTIOXIDANTS
ANTIVIRAL ACTIVITY
COXSACKIEVIRUS
ENTEROVIRAL INFECTION
ENTEROVIRUSES
LEUCOVERDAZYLES
VERDAZYLES
2 (1 ARYL 3 PHENYL 5,,6 DIHYDRO 4H 1,2,4,5 TETRAZIN 1 YL) 1,3 BENZOTHIAZOLE
5 ARYL 1 (BENZO[D]THIAZOL 2 YL) 3 PHENYL 6 VINYLVERDAZYL
6 ALKYL 5 ARYL 1 (BENZO[D]THIAZOL 2 YL) 3 PHENYLVERDAZYL
ANTIVIRUS AGENT
CYTOPROTECTIVE AGENT
FREE RADICAL
HETEROCYCLIC COMPOUND
KUHN VERDAZYL
LEUCOVERDAZYL DERIVATIVE
PLECONARIL
UNCLASSIFIED DRUG
VERDAZYL DERIVATIVE
VIRUS DNA
VIRUS RNA
ANIMAL CELL
ANTIVIRAL ACTIVITY
ARTICLE
ASSAY
CC50 (CYTOTOXIC CONCENTRATION)
CELL CULTURE
CELL PROTECTION
CELL SURVIVAL
CONTROLLED STUDY
COXSACKIE VIRUS INFECTION
COXSACKIEVIRUS B3
COXSACKIEVIRUS B4
COXSACKIEVIRUS B5
CYTOPATHOGENIC EFFECT
CYTOTOXICITY
DRUG EFFICACY
DRUG MECHANISM
EC50
ENTEROVIRUS B
HUMAN ADENOVIRUS 5
HUMAN ALPHAHERPESVIRUS 1
IC50
IN VITRO STUDY
INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1))
LIFE CYCLE
NONHUMAN
PRECURSOR
TIME OF ADDITION ASSAY
VIRAL YIELD REDUCTION ASSAY
VIROSTATIC ACTIVITY
VIRUS CAPSID
VIRUS INHIBITION
VIRUS LOAD
 
Описание Enteroviruses are non-enveloped viruses of Enterovirus genus, Picornaviridae family, causing a variety of human diseases: from acute respiratory and intestinal infections to more severe pathologies including poliomyelitis, encephalitis, myocarditis, pancreatitis. Currently, no approved direct-acting antiviral drugs for treatment of enterovirus infections exists, whereas vaccination is available only for prevention of poliomyelitis and enterovirus 71 infection. Therefore, it is promising to conduct a search for inhibitors of enteroviruses life cycle in drug development to treat enterovirus infections. Here, antiviral properties of stable free radicals, verdazyls, and their precursors, leucoverdazyls, were investigated. It has been shown that leucoverdazyls vs verdazyls increased the survival of permissive cell culture infected with coxsackievirus. The activity range of the lead leucoverdazyl against RNA-containing and DNA-containing human viruses (in the viral yield reduction assay) and its proposed mechanism of action (time of addition assay) was studied. The lead compound suppressed reproduction of group B enteroviruses in vitro, with modest activity against influenza A virus and no activity against herpes virus type 1 and adenovirus type 5. The maximum decrease in viral titers was observed upon its addition to infected cells during early and middle stages of the virus life cycle. Thus, we concluded that the studied compound has a pronounced inhibitory activity against group B enteroviruses not belonging to the class of capsid binder inhibitors, without virucidal properties. Previously, we described antioxidant properties of leucoverdazyls. It is known that many viral infections are accompanied by production of reactive oxygen species and oxidative stress, and some compounds with antioxidant properties exhibit antiviral potential. Targeted chemical modifications of leucoverdazyls and further studies of leucoverdazyl mechanism of action as well as in vivo animal studies are needed. However, the results obtained may be useful for future development of new antiviral drugs to treat enteroviral infections. © Volobueva A.S. et al., 2023.
The work was supported by a grant for young scientists from the St. Petersburg Pasteur Institute.
 
Дата 2024-04-05T16:19:57Z
2024-04-05T16:19:57Z
2023
 
Тип Article
Journal article (info:eu-repo/semantics/article)
|info:eu-repo/semantics/publishedVersion
 
Идентификатор Volobueva, AS, Zarubaev, VV, Fedorchenko, TG, Lipunova, GN, Tungusov, VN & Chupakhin, ON 2023, 'Antiviral properties of verdazyls and leucoverdazyls and their activity against group B enteroviruses', Russian Journal of Infection and Immunity, Том. 13, № 1, стр. 107-118. https://doi.org/10.15789/2220-7619-VAL-2065
Volobueva, A. S., Zarubaev, V. V., Fedorchenko, T. G., Lipunova, G. N., Tungusov, V. N., & Chupakhin, O. N. (2023). Antiviral properties of verdazyls and leucoverdazyls and their activity against group B enteroviruses. Russian Journal of Infection and Immunity, 13(1), 107-118. https://doi.org/10.15789/2220-7619-VAL-2065
2220-7619
Final
All Open Access, Gold
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153481344&doi=10.15789%2f2220-7619-VAL-2065&partnerID=40&md5=f1f3cd04b1d8a60a5c6304c21c0b507c
https://iimmun.ru/iimm/article/download/2065/1688
http://elar.urfu.ru/handle/10995/130410
50455522
10.15789/2220-7619-VAL-2065
85153481344
 
Язык en
 
Права Open access (info:eu-repo/semantics/openAccess)
cc-by
https://creativecommons.org/licenses/by/4.0/
 
Формат application/pdf
 
Издатель Saint Petersburg Pasteur Institute
 
Источник Russian Journal of Infection and Immunity
Russian Journal of Infection and Immunity