ANTIVIRAL PROPERTIES OF VERDAZYLS AND LEUCOVERDAZYLS AND THEIR ACTIVITY AGAINST GROUP B ENTEROVIRUSES
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригиналаПоле | Значение | |
Заглавие |
ANTIVIRAL PROPERTIES OF VERDAZYLS AND LEUCOVERDAZYLS AND THEIR ACTIVITY AGAINST GROUP B ENTEROVIRUSES
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Автор |
Volobueva, A. S.
Zarubaev, V. V. Fedorchenko, T. G. Lipunova, G. N. Tungusov, V. N. Chupakhin, O. N. |
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Тематика |
ANTIOXIDANTS
ANTIVIRAL ACTIVITY COXSACKIEVIRUS ENTEROVIRAL INFECTION ENTEROVIRUSES LEUCOVERDAZYLES VERDAZYLES 2 (1 ARYL 3 PHENYL 5,,6 DIHYDRO 4H 1,2,4,5 TETRAZIN 1 YL) 1,3 BENZOTHIAZOLE 5 ARYL 1 (BENZO[D]THIAZOL 2 YL) 3 PHENYL 6 VINYLVERDAZYL 6 ALKYL 5 ARYL 1 (BENZO[D]THIAZOL 2 YL) 3 PHENYLVERDAZYL ANTIVIRUS AGENT CYTOPROTECTIVE AGENT FREE RADICAL HETEROCYCLIC COMPOUND KUHN VERDAZYL LEUCOVERDAZYL DERIVATIVE PLECONARIL UNCLASSIFIED DRUG VERDAZYL DERIVATIVE VIRUS DNA VIRUS RNA ANIMAL CELL ANTIVIRAL ACTIVITY ARTICLE ASSAY CC50 (CYTOTOXIC CONCENTRATION) CELL CULTURE CELL PROTECTION CELL SURVIVAL CONTROLLED STUDY COXSACKIE VIRUS INFECTION COXSACKIEVIRUS B3 COXSACKIEVIRUS B4 COXSACKIEVIRUS B5 CYTOPATHOGENIC EFFECT CYTOTOXICITY DRUG EFFICACY DRUG MECHANISM EC50 ENTEROVIRUS B HUMAN ADENOVIRUS 5 HUMAN ALPHAHERPESVIRUS 1 IC50 IN VITRO STUDY INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)) LIFE CYCLE NONHUMAN PRECURSOR TIME OF ADDITION ASSAY VIRAL YIELD REDUCTION ASSAY VIROSTATIC ACTIVITY VIRUS CAPSID VIRUS INHIBITION VIRUS LOAD |
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Описание |
Enteroviruses are non-enveloped viruses of Enterovirus genus, Picornaviridae family, causing a variety of human diseases: from acute respiratory and intestinal infections to more severe pathologies including poliomyelitis, encephalitis, myocarditis, pancreatitis. Currently, no approved direct-acting antiviral drugs for treatment of enterovirus infections exists, whereas vaccination is available only for prevention of poliomyelitis and enterovirus 71 infection. Therefore, it is promising to conduct a search for inhibitors of enteroviruses life cycle in drug development to treat enterovirus infections. Here, antiviral properties of stable free radicals, verdazyls, and their precursors, leucoverdazyls, were investigated. It has been shown that leucoverdazyls vs verdazyls increased the survival of permissive cell culture infected with coxsackievirus. The activity range of the lead leucoverdazyl against RNA-containing and DNA-containing human viruses (in the viral yield reduction assay) and its proposed mechanism of action (time of addition assay) was studied. The lead compound suppressed reproduction of group B enteroviruses in vitro, with modest activity against influenza A virus and no activity against herpes virus type 1 and adenovirus type 5. The maximum decrease in viral titers was observed upon its addition to infected cells during early and middle stages of the virus life cycle. Thus, we concluded that the studied compound has a pronounced inhibitory activity against group B enteroviruses not belonging to the class of capsid binder inhibitors, without virucidal properties. Previously, we described antioxidant properties of leucoverdazyls. It is known that many viral infections are accompanied by production of reactive oxygen species and oxidative stress, and some compounds with antioxidant properties exhibit antiviral potential. Targeted chemical modifications of leucoverdazyls and further studies of leucoverdazyl mechanism of action as well as in vivo animal studies are needed. However, the results obtained may be useful for future development of new antiviral drugs to treat enteroviral infections. © Volobueva A.S. et al., 2023.
The work was supported by a grant for young scientists from the St. Petersburg Pasteur Institute. |
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Дата |
2024-04-05T16:19:57Z
2024-04-05T16:19:57Z 2023 |
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Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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Идентификатор |
Volobueva, AS, Zarubaev, VV, Fedorchenko, TG, Lipunova, GN, Tungusov, VN & Chupakhin, ON 2023, 'Antiviral properties of verdazyls and leucoverdazyls and their activity against group B enteroviruses', Russian Journal of Infection and Immunity, Том. 13, № 1, стр. 107-118. https://doi.org/10.15789/2220-7619-VAL-2065
Volobueva, A. S., Zarubaev, V. V., Fedorchenko, T. G., Lipunova, G. N., Tungusov, V. N., & Chupakhin, O. N. (2023). Antiviral properties of verdazyls and leucoverdazyls and their activity against group B enteroviruses. Russian Journal of Infection and Immunity, 13(1), 107-118. https://doi.org/10.15789/2220-7619-VAL-2065 2220-7619 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153481344&doi=10.15789%2f2220-7619-VAL-2065&partnerID=40&md5=f1f3cd04b1d8a60a5c6304c21c0b507c https://iimmun.ru/iimm/article/download/2065/1688 http://elar.urfu.ru/handle/10995/130410 50455522 10.15789/2220-7619-VAL-2065 85153481344 |
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Язык |
en
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Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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Формат |
application/pdf
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Издатель |
Saint Petersburg Pasteur Institute
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Источник |
Russian Journal of Infection and Immunity
Russian Journal of Infection and Immunity |
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