Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation
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| Автор |
Mostafa, A. M. A.
Zakaly, H. M. H. Issa, S. A. M. Uosif, M. A. M. Alrowaili, Z. A. Zhukovsky, M. V. |
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| Тематика |
BIOLOGICAL DISTRIBUTION
CLINICAL DATA COEFFICIENTS OF TRANSITION EXPONENTIAL FUNCTION RADIOPHARMACEUTICALS |
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| Описание |
This study highlights the use of 89Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys, inflammations, and tumors, and analyzes the maximum amount of nuclear transformation per Bq intake for each organ. The retention time of the maximum nuclear transformation and the absorbed doses of the drug in various organs and tissues are also examined. Data from clinical and laboratory studies on radiopharmaceuticals are used to estimate the coefficients of transition. The accumulation and excretion of the radiopharmaceutical in the organs is assumed to follow an exponential law. The coefficients of transition from the organs to the blood and vice versa are estimated using a combination of statistical programs and digitized data from the literature. WinAct and IDAC 2.1 software are used to calculate the distribution of the radiopharmaceutical in the human body and to estimate the absorbed doses in organs and tissues. The results of this study can provide valuable information for the biokinetic modeling of wide-spectrum diagnostic radiopharmaceuticals. The results show that 89Zr-oxalate has a high affinity for bones and a relatively low impact on healthy organs, making it helpful in targeting bone metastases. This study provides valuable information for further research on the development of this drug for potential clinical applications. © 2023 by the authors.
Al Jouf University; Deanship of Scientific Research, University of Jordan, DSR: DSR2022-RG-0124 This work was funded by the Deanship of Scientific Research at Jouf University under grant no. (DSR2022-RG-0124). The authors extend their appreciation to the Deanship of Scientific Research at Jouf University for funding this work through research group no. (DSR2022-RG-0124). |
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| Дата |
2024-04-05T16:20:00Z
2024-04-05T16:20:00Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Mostafa, AMA, Zakaly, HMH, Issa, SAM, Uosif, MAM, Alrowaili, ZA & Zhukovsky, MV 2023, 'Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation', Biomedicines, Том. 11, № 4, 1173. https://doi.org/10.3390/biomedicines11041173
Mostafa, A. M. A., Zakaly, H. M. H., Issa, S. A. M., Uosif, M. A. M., Alrowaili, Z. A., & Zhukovsky, M. V. (2023). Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation. Biomedicines, 11(4), [1173]. https://doi.org/10.3390/biomedicines11041173 2227-9059 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153708297&doi=10.3390%2fbiomedicines11041173&partnerID=40&md5=8e739c10880d5c64815ba1620606cb92 https://www.mdpi.com/2227-9059/11/4/1173/pdf?version=1681391446 http://elar.urfu.ru/handle/10995/130414 10.3390/biomedicines11041173 85153708297 000977172000001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Biomedicines
Biomedicines |
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