Absolute Stereochemistry and Cytotoxic Effects of Vismione E from Marine Sponge-Derived Fungus Aspergillus sp. 1901NT-1.2.2
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Absolute Stereochemistry and Cytotoxic Effects of Vismione E from Marine Sponge-Derived Fungus Aspergillus sp. 1901NT-1.2.2
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| Автор |
Girich, E. V.
Trinh, P. T. H. Nesterenko, L. E. Popov, R. S. Kim, N. Y. Rasin, A. B. Menchinskaya, E. S. Kuzmich, A. S. Chingizova, E. A. Minin, A. S. Ngoc, N. T. D. Van, T. T. T. Yurchenko, E. A. Yurchenko, A. N. Berdyshev, D. V. |
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| Тематика |
ASPERGILLUS
CYTOTOXICITY HPLC MS MARINE-DERIVED FUNGUS MCF-7 PROLIFERATION SECONDARY METABOLITES VISMIONE E ANTHRAQUINONE DERIVATIVE CYTOTOXIC AGENT INOSINATE DEHYDROGENASE TERPENE DERIVATIVE UNCLASSIFIED DRUG VISMIONE E ANTHRAQUINONE DERIVATIVE ANTINEOPLASTIC AGENT ANIMAL CELL ARTICLE ASPERGILLUS CELL CYCLE G1 PHASE CELL MIGRATION CELL PROLIFERATION CELL VIABILITY CONTROLLED STUDY CYTOTOXICITY DRUG ISOLATION DRUG TARGETING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY HUMAN HUMAN CELL IC50 MASS SPECTROMETRY MCF-10A CELL LINE MCF-7 CELL LINE MOLECULAR DOCKING NONHUMAN QUANTUM CHEMISTRY STEREOCHEMISTRY ANIMAL ASPERGILLUS CHEMICAL STRUCTURE CHEMISTRY FUNGUS SPONGE (PORIFERA) TUMOR CELL LINE ANIMALS ANTHRAQUINONES ANTINEOPLASTIC AGENTS ASPERGILLUS CELL LINE, TUMOR FUNGI HUMANS MOLECULAR DOCKING SIMULATION MOLECULAR STRUCTURE PORIFERA |
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| Описание |
The metabolic profile of the Aspergillus sp. 1901NT-1.2.2 sponge-associated fungal strain was investigated using the HPLC MS technique, and more than 23 peaks in the HPLC MS chromatogram were detected. Only two minor peaks were identified as endocrocin and terpene derivative MS data from the GNPS database. The main compound was isolated and identified as known anthraquinone derivative vismione E. The absolute stereochemistry of vismione E was established for the first time using ECD and quantum chemical methods. Vismione E showed high cytotoxic activity against human breast cancer MCF-7 cells, with an IC50 of 9.0 µM, in comparison with low toxicity for normal human breast MCF-10A cells, with an IC50 of 65.3 µM. It was found that vismione E inhibits MCF-7 cell proliferation and arrests the cell cycle in the G1 phase. Moreover, the negative influence of vismione E on MCF-7 cell migration was detected. Molecular docking of vismione E suggested the IMPDH2 enzyme as one of the molecular targets for this anthraquinone derivative. © 2023 by the authors.
Vietnam Academy of Science and Technology, VAST: VAST06.02/21-22; Russian Foundation for Basic Research, РФФИ: 21-53-54005 This research was funded by the Russian Foundation for Basic Research (grant number 21-53-54005) (chemical and bioassay study) and the Vietnam Academy of Science and Technology (grant number VAST06.02/21-22) (microbiological study). |
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| Дата |
2024-04-05T16:22:20Z
2024-04-05T16:22:20Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Girich, EV, Trinh, PTH, Nesterenko, LE, Popov , RS, Kim, NY, Rasin , AB, Menchinskaya, ES, Kuzmich, AS, Chingizova, EA, Minin, AS, Ngoc, NTD, Van, TTT, Yurchenko, EA, Yurchenko , AN & Berdyshev, DV 2023, 'Absolute Stereochemistry and Cytotoxic Effects of Vismione E from Marine Sponge-Derived Fungus Aspergillus sp. 1901NT-1.2.2', International Journal of Molecular Sciences, Том. 24, № 9, 8150. https://doi.org/10.3390/ijms24098150
Girich, E. V., Trinh, P. T. H., Nesterenko, L. E., Popov , R. S., Kim, N. Y., Rasin , A. B., Menchinskaya, E. S., Kuzmich, A. S., Chingizova, E. A., Minin, A. S., Ngoc, N. T. D., Van, T. T. T., Yurchenko, E. A., Yurchenko , A. N., & Berdyshev, D. V. (2023). Absolute Stereochemistry and Cytotoxic Effects of Vismione E from Marine Sponge-Derived Fungus Aspergillus sp. 1901NT-1.2.2. International Journal of Molecular Sciences, 24(9), [8150]. https://doi.org/10.3390/ijms24098150 1661-6596 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159629051&doi=10.3390%2fijms24098150&partnerID=40&md5=f21507a436fe188c25d2627d7aeaa519 https://www.mdpi.com/1422-0067/24/9/8150/pdf?version=1683192483 http://elar.urfu.ru/handle/10995/130487 10.3390/ijms24098150 85159629051 000987683500001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
International Journal of Molecular Sciences
International Journal of Molecular Sciences |
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