Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates
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| Автор |
Kalinina, T. A.
Balandina, V. I. Obydennov, K. L. Slepukhin, P. A. Fan, Z. Bakulev, V. A. Glukhareva, T. V. |
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| Тематика |
1,2,3-THIADIAZOLES
ACYLALANINE FUNGICIDES ANTIFUNGAL ACTIVITY ISOTHIAZOLES ISOTIANIL N-ACYL-N-ARYLALANINES PLANT PROTECTION TIADINIL ANTIFUNGAL AGENT FUNGICIDE N-(3-CHLORO-4-METHYLPHENYL)-4-METHYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE THIADIAZOLE DERIVATIVE CHEMICAL STRUCTURE PLANT STRUCTURE ACTIVITY RELATION ANTIFUNGAL AGENTS FUNGICIDES, INDUSTRIAL MOLECULAR STRUCTURE PLANTS STRUCTURE-ACTIVITY RELATIONSHIP THIADIAZOLES |
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| Описание |
The addition of active groups of known fungicides, or systemic acquired resistance inducers, into novel compound molecules to search for potential antifungal compounds is a popular and effective strategy. In this work, a new series of N-acyl-N-arylalanines was developed and synthesized, in which 1,2,3-thiadiazol-5-ylcarbonyl or 3,4-dichloroisothiazol-5-ylcarbonyl (fragments from synthetic plant resistance activators tiadinil and isotianil, respectively) and a fragment of N-arylalanine, the toxophoric group of acylalanine fungicides. Several new synthesized compounds have shown moderate antifungal activity against fungi in vitro, such as B. cinerea, R. solani and S. sclerotiorum. In vivo tests against A. brassicicola showed that compound 1d was 92% effective at a concentration of 200 µg/mL, similar to level of tiadinil, a known inducer of systemic resistance. Thus, 1d could be considered a new candidate fungicide for further detailed study. The present results will advance research and influence the search for more promising fungicides for disease control in agriculture. © 2023 by the authors.
Russian Science Foundation, RSF: 22-26-20124 This research was supported by the Russian Science Foundation and Government of Sverdlovsk region, Joint Grant No 22-26-20124, https://rscf.ru/en/project/22-26-20124/ (accessed on 1 January 2023). |
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| Дата |
2024-04-05T16:22:26Z
2024-04-05T16:22:26Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Kalinina, TA, Balandina, VI, Obydennov, KL, Slepukhin, PA, Fan, Z, Bakulev, VA & Glukhareva, TV 2023, 'Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates', Molecules, Том. 28, № 1, 419. https://doi.org/10.3390/molecules28010419
Kalinina, T. A., Balandina, V. I., Obydennov, K. L., Slepukhin, P. A., Fan, Z., Bakulev, V. A., & Glukhareva, T. V. (2023). Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates. Molecules, 28(1), [419]. https://doi.org/10.3390/molecules28010419 1420-3049 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145692224&doi=10.3390%2fmolecules28010419&partnerID=40&md5=006269e854f70e1c2016dceb39c7d35c https://www.mdpi.com/1420-3049/28/1/419/pdf?version=1672735384 http://elar.urfu.ru/handle/10995/130492 10.3390/molecules28010419 85145692224 000909975500001 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//22-29-01514
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Molecules
Molecules |
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