Application of InP/ZnSe/ZnS Quantum Dots in the Treatment of Experimental Antibiotic-Resistant Endophthalmitis in vivo
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Application of InP/ZnSe/ZnS Quantum Dots in the Treatment of Experimental Antibiotic-Resistant Endophthalmitis in vivo
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| Автор |
Ponomarev, V. O.
Kazaykin, V. N. Tkachenko, K. A. Vokhmintsev, A. S. Vainshtein, I. A. Zhdanov, A. E. |
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| Тематика |
ANTI-INFECTIVE ACTIVITY
ANTIBIOTIC RESISTANCE BACTERIAL ENDOPHTHALMITIS CONJUGATES QUANTUM DOTS OXYGEN QUANTUM DOT SUPEROXIDE VANCOMYCIN ANIMAL EXPERIMENT ANIMAL MODEL ANTERIOR EYE SEGMENT ANTIBACTERIAL ACTIVITY ANTIBIOTIC RESISTANCE AQUEOUS SOLUTION ARTICLE BACTERIAL KINETICS BACTERIUM CULTURE BLUE LIGHT CONJUGATE CONTROLLED STUDY DISEASE MODEL ECHOGRAPHY ELECTRON MICROSCOPY ENDOPHTHALMITIS IN VIVO STUDY MALE METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS NEW ZEALAND RABBIT NONHUMAN PHYSICAL CHEMISTRY SPECTROPHOTOMETRY VANCOMYCIN RESISTANT STAPHYLOCOCCUS AUREUS |
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| Описание |
purpose: modeling of experimental antibiotic-resistant endophthalmitis on laboratory animals model describing the interaction of quantum dots and a biological organism and its physicochemical and kinetic aspects. material and methods. The object of the study is laboratory New Zealand rabbits (2 male, age 4 months, weight 3.5 kg). The inflammation inductor is the culture of Methicillin-Resistant Staphylococcus Aureus (MRSA). 1 mg/0.05 ml of vancomycin in combination with 0.5 μg (0.01 %)/0.05 ml by a solution of quantum dots InP/ZnSe/ZnS 660 was intravitreally administrated to the first rabbit. 1 mg/0.1 ml of vancomycin was intravitreally administrated to the second rabbit. Dynamic observation of the clinical process was performed daily by photo registration of the front segment and ultrasonic sonography. results. The conjugate based on 1 mg/0.05 ml vancomycin coupled with 0.5 μg (0.01 %)/0.05 ml quantum dots InP/ZnSe/ZnS 660 demonstrated high anti-infectious activity against vancomycin-resistant MRSA. It was shown that the effect of the above solution on MRSA is described by the one-time ability of quantum dots by using electron microscopy. The presence of superoxide radicals O2–• generation in an aqueous solution of quantum dots under the action of blue light has also been proven by spectrophotometric method. Conclusion. Conjugates based on quantum dots can be considered as one of the promising directions of treatment of antibiotic-resistant endophthalmitis. © 2023 Ophthalmology Publishing Group. All rights reserved.
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| Дата |
2024-04-05T16:22:50Z
2024-04-05T16:22:50Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Пономарев, ВО, Казайкин, ВН, Ткаченко, КА, Вохминцев, АС, Вайнштейн, ИА & Жданов, АЕ 2023, 'ПРИМЕНЕНИЕ КВАНТОВЫХ ТОЧЕК INP/ZNSE/ZNS В ЛЕЧЕНИИ ЭКСПЕРИМЕНТАЛЬНОГО АНТИБИОТИКОРЕЗИСТЕНТНОГО ЭНДОФТАЛЬМИТА IN VIVO', Офтальмология, Том. 20, № 1, стр. 120-127. https://doi.org/10.18008/1816-5095-2023-1-120-127
Пономарев, В. О., Казайкин, В. Н., Ткаченко, К. А., Вохминцев, А. С., Вайнштейн, И. А., & Жданов, А. Е. (2023). ПРИМЕНЕНИЕ КВАНТОВЫХ ТОЧЕК INP/ZNSE/ZNS В ЛЕЧЕНИИ ЭКСПЕРИМЕНТАЛЬНОГО АНТИБИОТИКОРЕЗИСТЕНТНОГО ЭНДОФТАЛЬМИТА IN VIVO. Офтальмология, 20(1), 120-127. https://doi.org/10.18008/1816-5095-2023-1-120-127 1816-5095 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160251822&doi=10.18008%2f1816-5095-2023-1-120-127&partnerID=40&md5=453e1fad97f05919dab1781b345328fb https://www.ophthalmojournal.com/opht/article/download/2050/1079 http://elar.urfu.ru/handle/10995/130506 50498919 10.18008/1816-5095-2023-1-120-127 85160251822 |
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| Язык |
ru
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Ophthalmology Publishing Group
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| Источник |
Ophthalmology in Russia
Oftalmologiya |
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