Design of Spherical Gel-Based Magnetic Composites: Synthesis and Characterization
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Design of Spherical Gel-Based Magnetic Composites: Synthesis and Characterization
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| Автор |
Shabadrov, P. A.
Safronov, A. P. Kurilova, N. M. Blyakhman, F. A. |
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| Тематика |
ALGINATE
BIOMEDICAL APPLICATIONS FERROGELS HYDROGELS MAGNETIC NANOPARTICLES MAGNETIC SPHERES POLYACRYLAMIDE |
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| Описание |
The purpose of the study was the synthesis and the physicochemical characterization of spherical beads of magnetically active composite ferrogels (FGs) with diameters of 2–3 mm for further application to the needs of targeted drug delivery and/or replacement therapy. Spherical FGs based on a physical network of calcium alginate (CaAlg), a chemical network of polyacrylamide (PAAm), and a combined network of calcium alginate and polyacrylamide (PAAm/CaAlg) were analyzed. FGs were filled with γ-Fe2O3 magnetic nanoparticles (MNPs) obtained by using the electrical explosion of wire method. A comparative study of the swelling behavior and of the structural features of the polymeric network in CaAlg, PAAm/CaAlg, and PAAm spherical beads was performed. It was shown that the densest network was provided by a combination of chemical and physical networking in PAAm/CaAlg FGs. If the physical network were removed from FGs it resulted in a substantial increase in the average diameter and the swelling ratio of spherical beads and a decrease in the MNPs concentration in the swollen FGs by approximately two times. It was shown that irrespective of the gel composition, the embedding of maghemite nanoparticles led to an increase in the swelling ratio of the polymeric network. This indicated the absence of strong intermolecular interactions between the polymer and the filler. The results obtained might be useful for the design of magnetically active spherical FG beads of a given size and controlled physicochemical properties. © 2023 by the authors.
Ministry of Health of the Russian Federation: 121032300335-1 The study was supported by the program of the Ministry of Health of the Russian Federation (project 121032300335-1). |
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| Дата |
2024-04-05T16:23:02Z
2024-04-05T16:23:02Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Shabadrov, PA, Safronov, AP, Kurilova, NM & Blyakhman, FA 2023, 'Design of Spherical Gel-Based Magnetic Composites: Synthesis and Characterization', Journal of Composites Science, Том. 7, № 5, 177. https://doi.org/10.3390/jcs7050177
Shabadrov, P. A., Safronov, A. P., Kurilova, N. M., & Blyakhman, F. A. (2023). Design of Spherical Gel-Based Magnetic Composites: Synthesis and Characterization. Journal of Composites Science, 7(5), [177]. https://doi.org/10.3390/jcs7050177 2504-477X Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160332846&doi=10.3390%2fjcs7050177&partnerID=40&md5=d79ccff63cf781a17e686c6702bb5abe https://www.mdpi.com/2504-477X/7/5/177/pdf?version=1684399331 http://elar.urfu.ru/handle/10995/130511 10.3390/jcs7050177 85160332846 000998257600001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Journal of Composites Science
Journal of Composites Science |
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