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Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids

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Поле Значение
 
Заглавие Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids
 
Автор Tseilikman, V. E.
Fedotova, J. O.
Tseilikman, O. B.
Novak, J.
Karpenko, M. N.
Maistrenko, V. A.
Lazuko, S. S.
Belyeva, L. E.
Kamel, M.
Buhler, A. V.
Kovaleva, E. G.
 
Тематика 11-Β-HYDROXYSTEROID DEHYDROGENASE TYPE 1
ANXIETY
CYP3A
GLUCOCORTICOIDS
MOLECULAR DYNAMICS
PTSD
TRANS-RESVERATROL
11BETA HYDROXYSTEROID DEHYDROGENASE 1
CORTICOSTERONE
CYTOCHROME P450 3A
HYDROCORTISONE
RESVERATROL
11BETA HYDROXYSTEROID DEHYDROGENASE
11BETA HYDROXYSTEROID DEHYDROGENASE 1
CORTICOSTERONE
CYTOCHROME P450 3A
GLUCOCORTICOID
HYDROXYSTEROID DEHYDROGENASE
RESVERATROL
ANIMAL EXPERIMENT
ANIMAL MODEL
ANIMAL TISSUE
ANXIETY
ARTICLE
CONTROLLED STUDY
CORTICOSTEROID METABOLISM
CORTICOSTERONE BLOOD LEVEL
DRUG BINDING SITE
DRUG CONFORMATION
DRUG PROTEIN BINDING
ENZYME ACTIVITY
HUMAN
LIVER METABOLISM
MALE
MOLECULAR DOCKING
MOLECULAR DYNAMICS
NONHUMAN
POSTTRAUMATIC STRESS DISORDER
PROTEIN CONFORMATION
RAT
TRANS ISOMER
ANIMAL
GENETICS
METABOLISM
POSTTRAUMATIC STRESS DISORDER
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
11-BETA-HYDROXYSTEROID DEHYDROGENASES
ANIMALS
CORTICOSTERONE
CYTOCHROME P-450 CYP3A
GLUCOCORTICOIDS
HUMANS
HYDROXYSTEROID DEHYDROGENASES
RATS
RESVERATROL
STRESS DISORDERS, POST-TRAUMATIC
 
Описание Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity. Trans-resveratrol, a natural polyphenol, has been extensively studied for its antipsychiatric properties. Recently, protective effects of trans-resveratrol were found in relation to PTSD. Treatment of PTSD rats with trans-resveratrol allowed the rats to be divided into two phenotypes. The first phenotype is treatment-sensitive rats (TSR), and the second phenotype is treatment-resistant rats (TRRs). In TSR rats, trans-resveratrol ameliorated anxiety-like behavior and reversed plasma corticosterone concentration abnormalities. In contrast, in TRR rats, trans-resveratrol aggravated anxiety-like behavior and decreased plasma corticosterone concentration. In TSR rats, hepatic 11β-HSD-1 activity was suppressed, with a concomitant increase in CYP3A activity. In TRR rats, the activities of both enzymes were suppressed. Thus, the resistance of PTSD rats to trans-resveratrol treatment is associated with abnormalities in hepatic metabolism of glucocorticoids. The free energy of binding of resveratrol, cortisol, and corticosterone to the human CYP3A protein was determined using the molecular mechanics Poisson–Boltzmann surface area approach, indicating that resveratrol could affect CYP3A activity. © 2023 by the authors.
Russian Science Foundation, RSF: 23-15-20040
This research was funded by Russian Scientific Foundation, Regional grant (Chelyabinsk region) number 23-15-20040.
 
Дата 2024-04-05T16:25:48Z
2024-04-05T16:25:48Z
2023
 
Тип Article
Journal article (info:eu-repo/semantics/article)
|info:eu-repo/semantics/publishedVersion
 
Идентификатор Tseilikman, VE, Fedotova, JO, Tseilikman, OB, Novak, J, Karpenko, MN, Maistrenko, VA, Lazuko, SS, Belyeva, LE, Kamel, M, Buhler , AV & Kovaleva, EG 2023, 'Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids', International Journal of Molecular Sciences, Том. 24, № 11, 9333. https://doi.org/10.3390/ijms24119333
Tseilikman, V. E., Fedotova, J. O., Tseilikman, O. B., Novak, J., Karpenko, M. N., Maistrenko, V. A., Lazuko, S. S., Belyeva, L. E., Kamel, M., Buhler , A. V., & Kovaleva, E. G. (2023). Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids. International Journal of Molecular Sciences, 24(11), [9333]. https://doi.org/10.3390/ijms24119333
1661-6596
Final
All Open Access, Gold, Green
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161670578&doi=10.3390%2fijms24119333&partnerID=40&md5=f83b2df92424eeba1c3db424ba05ab3d
https://www.mdpi.com/1422-0067/24/11/9333/pdf?version=1685331694
http://elar.urfu.ru/handle/10995/130554
10.3390/ijms24119333
85161670578
001005032200001
 
Язык en
 
Связанные ресурсы info:eu-repo/grantAgreement/RSF//23-15-20040
 
Права Open access (info:eu-repo/semantics/openAccess)
cc-by
https://creativecommons.org/licenses/by/4.0/
 
Формат application/pdf
 
Издатель Multidisciplinary Digital Publishing Institute (MDPI)
 
Источник International Journal of Molecular Sciences
International Journal of Molecular Sciences