Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies
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| Автор |
Kositsyn, Y. M.
de, Abreu, M. S. Kolesnikova, T. O. Lagunin, A. A. Poroikov, V. V. Harutyunyan, H. S. Yenkoyan, K. B. Kalueff, A. V. |
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| Тематика |
DEPRESSION
NOVEL MOLECULAR TARGETS PATHOGENESIS PSYCHOSIS SCHIZOPHRENIA ANTIDEPRESSANT AGENT BIOLOGICAL MARKER NEUROLEPTIC AGENT ANTIDEPRESSANT AGENT NEUROLEPTIC AGENT ANTIDEPRESSANT ACTIVITY BRAIN REGION COGNITIVE DEFECT COMPUTER MODEL CYTOKINE PRODUCTION DEPRESSION DRUG DEVELOPMENT HUMAN NEGATIVE SYNDROME NERVE CELL PLASTICITY NERVOUS SYSTEM INFLAMMATION NEUROTRANSMISSION NONHUMAN POSITIVE SYNDROME PRESCRIPTION PSYCHOPHARMACOTHERAPY PSYCHOSIS RECEPTOR DOWN REGULATION REVIEW SCHIZOPHRENIA TRANSLATIONAL RESEARCH ANTIDEPRESSIVE AGENTS ANTIPSYCHOTIC AGENTS HUMANS SCHIZOPHRENIA |
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| Описание |
Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development. © 2023 by the authors.
075-15-2021-684; 857600; 122030100170-5; Suzhou University of Science and Technology; State Committee of Science, SCS: N 10-14/23-I/YSMU This work was supported by the Republic of Armenia State Committee of Science (N 10-14/23-I/YSMU) and the European Union-funded H2020 COBRAIN project (857600). The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish. Computer-aided prediction of biological activity in this pharmacotherapeutic field (A.A.L. and V.V.P.) was overviewed within the framework of the Program for Basic Research in the Russian Federation for a long-term period (2021–2030) (project 122030100170-5). The research partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). A.V.K. is supported by St. Petersburg State University 2023 budget assignment funds. T.O.K. is supported by Neurobiology program of Sirius University of Science and Technology 2023 research budget funds. The authors thank Hasmik Harutyunyan (COBRAIN Center, Yerevan State Medical University) for help with graphical illustrations. |
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| Дата |
2024-04-05T16:25:49Z
2024-04-05T16:25:49Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Kositsyn, YM, De Abreu, MS, Kolesnikova, TO, Lagunin, AA, Poroikov, VV, Harutyunyan , HS, Yenkoyan, KB & Kalueff, AV 2023, 'Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies', International Journal of Molecular Sciences, Том. 24, № 11, 9482. https://doi.org/10.3390/ijms24119482
Kositsyn, Y. M., De Abreu, M. S., Kolesnikova, T. O., Lagunin, A. A., Poroikov, V. V., Harutyunyan , H. S., Yenkoyan, K. B., & Kalueff, A. V. (2023). Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. International Journal of Molecular Sciences, 24(11), [9482]. https://doi.org/10.3390/ijms24119482 1661-6596 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161707246&doi=10.3390%2fijms24119482&partnerID=40&md5=fabbe93d04283e1d399cce9beef7a4a1 https://www.mdpi.com/1422-0067/24/11/9482/pdf?version=1685435671 http://elar.urfu.ru/handle/10995/130557 10.3390/ijms24119482 85161707246 001006546200001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
International Journal of Molecular Sciences
International Journal of Molecular Sciences |
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