Features of the response to subchronic low-dose exposure to copper oxide nanoparticles in rats
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Features of the response to subchronic low-dose exposure to copper oxide nanoparticles in rats
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| Автор |
Sutunkova, M. P.
Ryabova, Y. V. Minigalieva, I. A. Bushueva, T. V. Sakhautdinova, R. R. Bereza, I. A. Shaikhova, D. R. Amromina, A. M. Chemezov, A. I. Shelomencev, I. G. Amromin, L. A. Valamina, I. E. Toropova, L. V. |
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| Тематика |
COPPER
CUPROUS OXIDE METAL NANOPARTICLE OXIDE ANIMAL HUMAN RAT ANIMALS COPPER HUMANS METALS NANOPARTICLES OXIDES RATS |
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| Описание |
Copper is an essential trace element for human health and, at the same time, a major industrial metal widely used both in its elemental form and in compounds. We conducted a dose-dependent assessment of the response of outbred albino male rats to subchronic low-dose exposure to copper oxide nanoparticles administered intraperitoneally at cumulative doses of 18 and 36 mg/kg during 6 weeks to exposure groups 1 and 2, respectively. We observed disorders at different levels of organization of the body in the exposed animals, from molecular to organismal. The observed decrease in the activity of succinate dehydrogenase in nucleated blood cells gave evidence of impaired bioenergetics processes. In view of the results of the metabolomics analysis, we assume mitochondrial damage and contribution of apoptotic processes to the pathology induced by copper poisoning. We also assume neurodegenerative effects based on the assessed morphological parameters of the nervous system, results of behavioral tests, and a decreased level of expression of genes encoding NMDA receptor subunits in the hippocampus. The hepatotoxic effect noted by a number of metabolomics-based, biochemical, and cytological indicators was manifested by the impaired protein-synthesizing function of the liver and enhanced degenerative processes in its cells. We also observed a nephrotoxic effect of nanosized copper oxide with a predominant lesion of proximal kidney tubules. At the same time, both doses tested demonstrated such positive health effects as a statistically significant decrease in the activity of alkaline phosphatase and the nucleated blood cell DNA fragmentation factor. Judging by the changes observed, the cumulative dose of copper oxide nanoparticles of 18 mg/kg body weight administered intraperitoneally approximates the threshold one for rats. The established markers of health impairments may serve as a starting point in the development of techniques of early diagnosis of copper poisoning. © 2023, The Author(s).
Friedrich-Schiller-Universität Jena, FSU; Ministry of Education and Science of the Russian Federation, Minobrnauka; Ministry of Science and Higher Education of the Russian Federation: Priority – 2030 Open Access funding enabled and organized by Projekt DEAL. The research funding from Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers for funding the experimental materials and facilities is gratefully acknowledged. The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority–2030 Program) for experiment implementation and analysis of its results is gratefully acknowledged. The authors would like to express their deepest gratitude to the staff of the Ural Center for Shared Use “Modern Nanotechnologies” of the Ural Federal University named after the First Russian President Boris Yeltsin and personally to Professor Vladimir Ya. Shur, Director of the Center, for invaluable support in conducting this study by synthesizing suspensions of the nanoparticles studied. We are also grateful to the staff of the Central Research Laboratory of the Ural State Medical University and personally to Professor Oleg G. Makeyev for establishing genomic DNA fragmentation. |
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| Дата |
2024-04-05T16:28:33Z
2024-04-05T16:28:33Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Sutunkova, M, Ryabova, Y, Minigalieva, I, Bushueva, T, Sakhautdinova, R, Bereza, IA, Shaikhova, D, Amromina, AM, Chemezov, AI, Shelomencev, I, Amromin, L, Valamina, I & Toropova, L 2023, 'Features of the response to subchronic low-dose exposure to copper oxide nanoparticles in rats', Scientific Reports, Том. 13, № 1, 11890. https://doi.org/10.1038/s41598-023-38976-z
Sutunkova, M., Ryabova, Y., Minigalieva, I., Bushueva, T., Sakhautdinova, R., Bereza, I. A., Shaikhova, D., Amromina, A. M., Chemezov, A. I., Shelomencev, I., Amromin, L., Valamina, I., & Toropova, L. (2023). Features of the response to subchronic low-dose exposure to copper oxide nanoparticles in rats. Scientific Reports, 13(1), [11890]. https://doi.org/10.1038/s41598-023-38976-z 2045-2322 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165553756&doi=10.1038%2fs41598-023-38976-z&partnerID=40&md5=93ab2392e18959b70eeb70dcc28fb0fe https://www.nature.com/articles/s41598-023-38976-z.pdf http://elar.urfu.ru/handle/10995/130663 10.1038/s41598-023-38976-z 85165553756 001034811000009 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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application/pdf
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Nature Research
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| Источник |
Scientific Reports
Scientific Reports |
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