Pharmacological Potential of Betulin as a Multitarget Compound
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Pharmacological Potential of Betulin as a Multitarget Compound
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| Автор |
Adepoju, F. O.
Duru, K. C. Li, E. Kovaleva, E. G. Tsurkan, M. V. |
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| Тематика |
ANTI-INFLAMMATORY
BETULIN HEPATOPROTECTIVE INFLAMMATION NATURAL PRODUCTS (MAPK, NRF2, NFΚB) ABC TRANSPORTER A1 ABC TRANSPORTER G1 ADIPONECTIN AGGRECAN ALANINE AMINOTRANSFERASE ALPHA GLUCOSIDASE ALPHA SMOOTH MUSCLE ACTIN AMYLASE ASPARTATE AMINOTRANSFERASE BETULIN CASPASE 12 CASPASE 3 CASPASE 7 CASPASE 8 CASPASE 9 CD68 ANTIGEN CISPLATIN COLLAGEN TYPE 1 COLLAGEN TYPE 2 COLLAGENASE 3 CRYOPYRIN CYTOCHROME P450 2E1 EPIDERMAL GROWTH FACTOR FATTY ACID SYNTHASE GAMMA INTERFERON GELATINASE A GLUTATHIONE GLUTATHIONE PEROXIDASE GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153 HEME OXYGENASE 1 HIGH MOBILITY GROUP B1 PROTEIN HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE KINASE IMMUNOGLOBULIN ENHANCER BINDING PROTEIN INTERLEUKIN 12P35 INTERLEUKIN 12P70 INTERLEUKIN 17 INTERLEUKIN 1ALPHA INTERLEUKIN 1BETA INTERLEUKIN 1BETA CONVERTING ENZYME MITOGEN ACTIVATED PROTEIN KINASE MITOGEN ACTIVATED PROTEIN KINASE 1 MITOGEN ACTIVATED PROTEIN KINASE 3 OSTEOGENIC PROTEIN 1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA PROSTAGLANDIN E2 PROTEIN BAX PROTEIN BCL 2 PROTEIN P53 PURINERGIC P2X7 RECEPTOR RANTES SIRTUIN 1 STAT3 PROTEIN STEROL REGULATORY ELEMENT BINDING PROTEIN 1 STEROL REGULATORY ELEMENT BINDING PROTEIN 1C SYNAPTOPHYSIN SYNAPTOTAGMIN I TOLL LIKE RECEPTOR 4 TRANSCRIPTION FACTOR NRF2 TRANSFORMING GROWTH FACTOR BETA TRIACYLGLYCEROL TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6 VASCULOTROPIN X LINKED INHIBITOR OF APOPTOSIS BETULIC ACID BETULIN CYTOKINE IMMUNOGLOBULIN ENHANCER BINDING PROTEIN TRITERPENE 786-O CELL LINE A-549 CELL LINE ACACIA AURICULIFORMIS AKT SIGNALING ALNUS GLUTINOSA AML12 CELL LINE ANEMONE RADDEANA ANTIDIABETIC ACTIVITY ANTIINFLAMMATORY ACTIVITY APOPTOSIS BALIOSPERMUM MONTANUM BETULA PENDULA BETULA PUBESCENS CAKI-2 CELL LINE CARDIOVASCULAR DISEASE CELTIS SINENSIS CROTON BONPLANDIANUS DIABETES MELLITUS DOLIOCARPUS DENTATUS ENZYME ACTIVITY EUPHORBIA HYSSOPIFOLIA FOMES FOMENTARIUS FTC-238 CELL LINE H9C2(2-1) CELL LINE HCT 116 CELL LINE HEDYOTIS HEDYOTIDEA HELA CELL LINE HEP-G2 CELL LINE HSC-T6 CELL LINE HUMAN HYGROPHILA AURICULATA HYPERGLYCEMIA IC50 INFLAMMATION INONOTUS OBLIQUUS LIGARIA CUNEIFOLIA LIVER DISEASE MATAYBA ELAEAGNOIDES MCF-7 CELL LINE MEDICINAL PLANT MG-63 CELL LINE NCI-H460 CELL LINE NEOPLASM NONHUMAN OUGENIA DALBERGIOIDES OVCAR-3 CELL LINE OXIDATIVE STRESS PAECILOMYCES PC-3 [HUMAN PROSTATE CARCINOMA] CELL LINE PLEUROSTYLIA CAPENSIS PROTEIN EXPRESSION PTERODON EMARGINATUS PYROLA DECORATE QUERCUS INCANA RAW 264.7 CELL LINE REVIEW RHIZOPHORA MUCRONATA SCHLEICHERA OLEOSA SGC-7901 CELL LINE SIGNAL TRANSDUCTION SK-HEP-1 CELL LINE T-47D CELL LINE TE 671 CELL LINE TECTONA GRANDIS ULCERATIVE COLITIS VACHELLIA NILOTICA VISCUM COLORATUM WOUND HEALING XANTHIUM SIBIRICUM INFLAMMATION METABOLISM BETULINIC ACID CYTOKINES HUMANS INFLAMMATION NF-KAPPA B TRITERPENES |
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| Описание |
Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing properties. Despite having a wide range of pharmacological targets, no studies have proposed betulin as a multitarget compound. Betulin has protective effects against cardiovascular and liver diseases, cancer, diabetes, oxidative stress, and inflammation. It reduces postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase activity, combats tumor cells by inducing apoptosis and inhibiting metastatic proteins, and modulates chronic inflammation by blocking the expression of proinflammatory cytokines via modulation of the NFκB and MAPKs pathways. Given its potential to influence diverse biological networks with high target specificity, it can be hypothesized that betulin may eventually become a new lead for drug development because it can modify a variety of pharmacological targets. The summarized research revealed that the diverse beneficial effects of betulin in various diseases can be attributed, at least in part, to its multitarget anti-inflammatory activity. This review focuses on the natural sources, pharmacokinetics, pharmacological activity of betulin, and the multi-target effects of betulin on signaling pathways such as MAPK, NF-κB, and Nrf2, which are important regulators of the response to oxidative stress and inflammation in the body. © 2023 by the authors.
Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-1118 This research was funded by the Ministry of Science and Higher Education of the Russian Federation MEGAGRANT, contract No 075-15-2022-1118, 29 June 2022. |
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| Дата |
2024-04-05T16:28:47Z
2024-04-05T16:28:47Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Adepoju, FO, Duru, KC, Li, E, Kovaleva, EG & Tsurkan, MV 2023, 'Pharmacological Potential of Betulin as a Multitarget Compound', Biomolecules, Том. 13, № 7, 1105. https://doi.org/10.3390/biom13071105
Adepoju, F. O., Duru, K. C., Li, E., Kovaleva, E. G., & Tsurkan, M. V. (2023). Pharmacological Potential of Betulin as a Multitarget Compound. Biomolecules, 13(7), [1105]. https://doi.org/10.3390/biom13071105 2218-273X Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165972123&doi=10.3390%2fbiom13071105&partnerID=40&md5=a25a392047b3726c4030841102049f28 https://www.mdpi.com/2218-273X/13/7/1105/pdf?version=1689130309 http://elar.urfu.ru/handle/10995/130669 10.3390/biom13071105 85165972123 001039224200001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
Biomolecules
Biomolecules |
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