Directed graph mapping shows rotors maintain non-terminating and focal sources maintain self-terminating Torsade de Pointes in canine model
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Directed graph mapping shows rotors maintain non-terminating and focal sources maintain self-terminating Torsade de Pointes in canine model
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| Автор |
Van, Den, Abeele, R.
Hendrickx, S. Van, Nieuwenhuyse, E. Dunnink, A. Panfilov, A. V. Vos, M. A. Wülfers, E. M. Vandersickel, N. |
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| Тематика |
CARDIAC ARRHYTHMIAS
CHRONIC ATRIOVENTRICULAR BLOCK DIRECTED GRAPH MAPPING ELECTROPHYSIOLOGICAL MAPPING FOCAL SOURCES REENTRY TORSADE DE POINTES ANATOMICAL REENTRY ANIMAL EXPERIMENT ANIMAL MODEL ARTICLE ATRIOVENTRICULAR BLOCK CANIS CARDIOVASCULAR PARAMETERS CHRONIC ATRIOVENTRICULAR BLOCK CONTROLLED STUDY DATA ANALYSIS DIRECTED GRAPH MAPPING DISEASE MODEL ELECTROPHYSIOLOGICAL MAPPING FEMALE FOCAL BEAT FOCAL SOURCE FUNCTIONAL REENTRY HEART ARRHYTHMIA HEART ELECTROPHYSIOLOGY HEART FUNCTION MALE NON TERMINATING EPISODE NONHUMAN PATHOPHYSIOLOGY REENTRY ARRHYTHMIA ROTOR SELF TERMINATING EPISODE TORSADE DE POINTES |
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| Описание |
Torsade de Pointes is a polymorphic ventricular tachycardia which is as yet incompletely understood. While the onset of a TdP episode is generally accepted to be caused by triggered activity, the mechanisms for the perpetuation is still under debate. In this study, we analysed data from 54 TdP episodes divided over 5 dogs (4 female, 1 male) with chronic atrioventricular block. Previous research on this dataset showed both reentry and triggered activity to perpetuate the arrhythmia. 13 of those TdP episodes showed reentry as part of the driving mechanism of perpetuating the episode. The remaining 41 episodes were purely ectopic. Reentry was the main mechanism in long-lasting episodes (>14 beats), while focal sources were responsible for maintaining shorter episodes. Building on these results, we re-analysed the data using directed graph mapping This program uses principles from network theory and a combination of positional data and local activation times to identify reentry loops and focal sources within the data. The results of this study are twofold. First, concerning reentry loops, we found that on average non-terminating (NT) episodes (≥10 s) show significantly more simultaneous reentry loops than self-terminating (ST) TdP (<10 s). Non-terminating episodes have on average 2.72 ± 1.48 simultaneous loops, compared to an average of 1.33 ± 0.66 for self-terminating episodes. In addition, each NT episode showed a presence of (bi-)ventricular loops between 10.10% and 69.62% of their total reentry duration. Compared to the ST episodes, only 1 in 4 episodes (25%) showed (bi-)ventricular reentry, lasting only 7.12% of its total reentry duration. This suggests that while focal beats trigger TdP, macro-reentry and multiple simultaneous localized reentries are the major drivers of long-lasting episodes. Second, using heatmaps, we found focal sources to occur in preferred locations, instead of being distributed randomly. This may have implications on treatment if such focal origins can be disabled reliably. Copyright © 2023 Van Den Abeele, Hendrickx, Van Nieuwenhuyse, Dunnink, Panfilov, Vos, Wülfers and Vandersickel.
European Research Council, ERC; Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-304; Horizon 2020: 900008 This research was supported by a ‘Starting Grant’ from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant No. 900008), awarded to NV. In addition, research at Sechenov University was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World- Class Research Centers, “Digital Biodesign and Personalized Healthcare,” No. 075-15-2022-304. |
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| Дата |
2024-04-05T16:30:55Z
2024-04-05T16:30:55Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Van den abeele, R, Hendrickx, S, Van nieuwenhuyse, E, Dunnink, A, Panfilov, AV, Vos, MA, Wülfers, EM & Vandersickel, N 2023, 'Directed graph mapping shows rotors maintain non-terminating and focal sources maintain self-terminating Torsade de Pointes in canine model', Frontiers in Physiology, Том. 14, 1201260. https://doi.org/10.3389/fphys.2023.1201260
Van den abeele, R., Hendrickx, S., Van nieuwenhuyse, E., Dunnink, A., Panfilov, A. V., Vos, M. A., Wülfers, E. M., & Vandersickel, N. (2023). Directed graph mapping shows rotors maintain non-terminating and focal sources maintain self-terminating Torsade de Pointes in canine model. Frontiers in Physiology, 14, [1201260]. https://doi.org/10.3389/fphys.2023.1201260 1664-042X Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85167512398&doi=10.3389%2ffphys.2023.1201260&partnerID=40&md5=58500cad8c317ecd4d9048f9ab6d8a0b https://www.frontiersin.org/articles/10.3389/fphys.2023.1201260/pdf?isPublishedV2=False http://elar.urfu.ru/handle/10995/130708 10.3389/fphys.2023.1201260 85167512398 001044975100001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Frontiers Media SA
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| Источник |
Frontiers in Physiology
Frontiers in Physiology |
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