Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines
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| Автор |
Khan, M. A.
Amin, A. Farid, A. Ullah, A. Waris, A. Shinwari, K. Hussain, Y. Alsharif, K. F. Alzahrani, K. J. Khan, H. |
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| Тематика |
GENOMES
INTRACELLULAR BACTERIA PROTEOMICS TRANSCRIPTOMICS VACCINE DEVELOPMENT ANTHRAX VACCINE BCG VACCINE CHOLERA VACCINE HAEMOPHILUS INFLUENZAE TYPE B VACCINE INTRACELLULAR BACTERIAL PATHOGEN VACCINE ISONIAZID LIVE VACCINE MENINGOCOCCUS VACCINE PNEUMOCOCCUS VACCINE RIFAMPICIN TULAREMIA VACCINE UNCLASSIFIED DRUG VACCINE ANTIBIOTIC RESISTANCE ANTIGEN PURIFICATION ANTIGENICITY BACILLUS ANTHRACIS BACTERIAL INFECTION BACTERICIDAL ACTIVITY BRUCELLA BRUCELLOSIS CHLAMYDIA PNEUMONIAE DNA MICROARRAY ELECTROPHORESIS ENZYME LINKED IMMUNOSORBENT ASSAY EPITOPE MAPPING ESCHERICHIA COLI EYE INFECTION FEVER FLUORESCENCE ACTIVATED CELL SORTING FOOD POISONING GENOMICS HELICOBACTER PYLORI HUMAN IMMUNE SYSTEM IMMUNITY IMMUNOBLOTTING IMMUNOMICS LEGIONNAIRE DISEASE LEPROSY LIFE EXPECTANCY LIQUID CHROMATOGRAPHY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY LISTERIA MONOCYTOGENES MACHINE LEARNING MASS SPECTROMETRY MASTITIS METABOLOMICS METAGENOMICS MORBIDITY MORTALITY MYCOBACTERIUM TUBERCULOSIS NEISSERIA MENINGITIDIS OSTEOMYELITIS PATHOGENESIS PORPHYROMONAS GINGIVALIS PROTEOMICS REVIEW RICKETTSIA PROWAZEKII ROCKY MOUNTAIN SPOTTED FEVER SHIGELLOSIS STREPTOCOCCUS PNEUMONIAE STREPTOCOCCUS PYOGENES TRANSCRIPTOME SEQUENCING TUBERCULOSIS TYPHOID FEVER VACCINE DEVELOPMENT VACCINOLOGY |
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| Описание |
Infectious diseases continue to be a leading cause of morbidity and mortality worldwide. The majority of infectious diseases are caused by intracellular pathogenic bacteria (IPB). Historically, conventional vaccination drives have helped control the pathogenesis of intracellular bacteria and the emergence of antimicrobial resistance, saving millions of lives. However, in light of various limitations, many diseases that involve IPB still do not have adequate vaccines. In response to increasing demand for novel vaccine development strategies, a new area of vaccine research emerged following the advent of genomics technology, which changed the paradigm of vaccine development by utilizing the complete genomic data of microorganisms against them. It became possible to identify genes related to disease virulence, genetic patterns linked to disease virulence, as well as the genetic components that supported immunity and favorable vaccine responses. Complete genomic databases, and advancements in transcriptomics, metabolomics, structural genomics, proteomics, immunomics, pan-genomics, synthetic genomics, and population biology have allowed researchers to identify potential vaccine candidates and predict their effects in patients. New vaccines have been created against diseases for which previously there were no vaccines available, and existing vaccines have been improved. This review highlights the key issues and explores the evolution of vaccines. The increasing volume of IPB genomic data, and their application in novel genome-based techniques for vaccine development, were also examined, along with their characteristics, and the opportunities and obstacles involved. Critically, the application of genomics technology has helped researchers rapidly select and evaluate candidate antigens. Novel vaccines capable of addressing the limitations associated with conventional vaccines have been developed and pressing healthcare issues are being addressed. © 2022 by the authors.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
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| Дата |
2024-04-05T16:31:45Z
2024-04-05T16:31:45Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Khan, MA, Amin, A, Farid, A, Ullah, A, Waris, A, Shinwari, K, Hussain, Y, Alsharif, KF, Alzahrani, KJ & Khan, H 2023, 'Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines', Pharmaceutics, Том. 15, № 1, 152. https://doi.org/10.3390/pharmaceutics15010152
Khan, M. A., Amin, A., Farid, A., Ullah, A., Waris, A., Shinwari, K., Hussain, Y., Alsharif, K. F., Alzahrani, K. J., & Khan, H. (2023). Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines. Pharmaceutics, 15(1), [152]. https://doi.org/10.3390/pharmaceutics15010152 1999-4923 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146553515&doi=10.3390%2fpharmaceutics15010152&partnerID=40&md5=b49bbbd6268253445bd9b055d2b0f12d https://www.mdpi.com/1999-4923/15/1/152/pdf?version=1673504213 http://elar.urfu.ru/handle/10995/130737 10.3390/pharmaceutics15010152 85146553515 000927241400001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Pharmaceutics
Pharmaceutics |
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