Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols
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| Автор |
Nikiforov, E. A.
Vaskina, N. F. Moseev, T. D. Varaksin, M. V. Charushin, V. N. Chupakhin, O. N. |
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| Тематика |
AZAHETEROCYCLES
C-H FUNCTIONALIZATION IMIDAZOLES NUCLEOPHILIC SUBSTITUTION OF HYDROGEN THIOPHENOLS |
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| Описание |
A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully applied as a convenient tool to obtain a series of novel azaheterocyclic molecules, including water-soluble hydrochloride forms. Optimized reaction conditions found herein for the nucleophilic substitution of hydrogen (SNH) in non-aromatic azaheterocyclic substrates via the “addition-elimination” (SNH AE) scheme enabled 15 arylthiolated 2H-imidazoles to be prepared in yields of up to 90%. The developed methodology discloses an original synthetic way to obtain numerous azaheterocyclic molecules, which are of interest in the field of medicinal chemistry and materials science. © 2023 by the authors.
Russian Science Foundation, RSF: 23-63-10011 This work was financially supported by the Russian Science Foundation (RSF), project № 23-63-10011. |
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| Дата |
2024-04-05T16:32:57Z
2024-04-05T16:32:57Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Nikiforov, EA, Vaskina, NF, Moseev, TD, Varaksin, MV, Charushin, VN & Chupakhin, ON 2023, 'Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols', Chemistry (Switzerland), Том. 5, № 3, стр. 1477-1487. https://doi.org/10.3390/chemistry5030100
Nikiforov, E. A., Vaskina, N. F., Moseev, T. D., Varaksin, M. V., Charushin, V. N., & Chupakhin, O. N. (2023). Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols. Chemistry (Switzerland), 5(3), 1477-1487. https://doi.org/10.3390/chemistry5030100 2624-8549 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172091340&doi=10.3390%2fchemistry5030100&partnerID=40&md5=5db2a5dde03572a22524c4aa86be3c76 https://www.mdpi.com/2624-8549/5/3/100/pdf?version=1687603743 http://elar.urfu.ru/handle/10995/130796 10.3390/chemistry5030100 85172091340 001075747900001 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//23-63-10011
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
Chemistry
Chemistry (Switzerland) |
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