Remote Positioning of Spherical Alginate Ferrogels in a Fluid Flow by a Magnetic Field: Experimental and Computer Simulation
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Remote Positioning of Spherical Alginate Ferrogels in a Fluid Flow by a Magnetic Field: Experimental and Computer Simulation
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| Автор |
Blyakhman, F.
Safronov, A. Starodumov, I. Kuznetsova, D. Kurlyandskaya, G. |
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| Тематика |
ALGINATE GEL
BIOMEDICAL APPLICATIONS BIOPOLYMER DELIVERY SYSTEM FLUID FLOW MAGNETIC FIELD MAGNETIC PARTICLES SPHERICAL FERROGEL |
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| Описание |
This work belongs to the development of mechanical force-responsive drug delivery systems based on remote stimulation by an external magnetic field at the first stage, assisting the positioning of a ferrogel-based targeted delivery platform in a fluid flow. Magnetically active biopolymer beads were considered a prototype implant for the needs of replacement therapy and regenerative medicine. Spherical calcium alginate ferrogels (FGs)~2.4 mm in diameter, filled with a 12.6% weight fraction of magnetite particles of 200–300 nm in diameter, were synthesized. A detailed characterization of the physicochemical and magnetic properties of FGs was carried out, as were direct measurements of the field dependence of the attractive force for FG-beads. The hydrodynamic effects of the positioning of FG-beads in a fluid flow by a magnetic field were studied experimentally in a model vessel with a fluid stream. Experimental results were compared with the results of mathematical and computer modeling, showing reasonable agreement. The contributions of the hydrodynamic and magnetic forces acting on the FG-bead in a fluid flow were discussed. Obtained forces for a single ferrogel implant were as high as 0 to 10−4 N for the external field range of 0 to 35 kA/m, perfectly in the range of mechanical force stimuli in biological systems. © 2023 by the authors.
Ministry of Education and Science of the Russian Federation, Minobrnauka: FEUZ-2020-0051; Russian Science Foundation, RSF: 20-12-00031, 22-71-10071; Ministry of Health of the Russian Federation: 121032300335-1 The study was supported by the program of the Ministry of Health of the Russian Federation (project 121032300335-1). A.P. Safronov thanks the Russian Science Foundation (Grant No. 20-12-00031) for ¯financial support in the synthesis and characterization of FGs. I.O. Starodumov thanks the Russian Science Foundation (Grant No. 22-71-10071) for ¯financial support in the mathematical modeling and computer simulations. G.V. Kurlyandskaya thanks the Ministry of Science and Higher Education of the Russian Federation (Grant No. FEUZ-2020-0051) for financial support in the characterization of FG’s magnetic properties. |
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| Дата |
2024-04-05T16:33:06Z
2024-04-05T16:33:06Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Blyakhman, F, Safronov, A, Starodumov, I, Kuznetsova, D & Kurlyandskaya, G 2023, 'Remote Positioning of Spherical Alginate Ferrogels in a Fluid Flow by a Magnetic Field: Experimental and Computer Simulation', Gels, Том. 9, № 9, 711. https://doi.org/10.3390/gels9090711
Blyakhman, F., Safronov, A., Starodumov, I., Kuznetsova, D., & Kurlyandskaya, G. (2023). Remote Positioning of Spherical Alginate Ferrogels in a Fluid Flow by a Magnetic Field: Experimental and Computer Simulation. Gels, 9(9), [711]. https://doi.org/10.3390/gels9090711 2310-2861 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172258056&doi=10.3390%2fgels9090711&partnerID=40&md5=f94e003dacf9600bb297270570d759e0 https://www.mdpi.com/2310-2861/9/9/711/pdf?version=1693565490 http://elar.urfu.ru/handle/10995/130802 10.3390/gels9090711 85172258056 001073876000001 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//20-12-00031
info:eu-repo/grantAgreement/RSF//22-71-10071 |
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
Gels
Gels |
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