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Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

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Заглавие Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation
 
Автор Tseilikman, V. E.
Shatilov, V. A.
Zhukov, M. S.
Buksha, I. A.
Epitashvily, A. E.
Lipatov, I. A.
Aristov, M. R.
Koshelev, A. G.
Karpenko, M. N.
Traktirov, D. S.
Maistrenko, V. A.
Kamel, M.
Buhler, A. V.
Kovaleva, E. G.
Kalinina, T. S.
Pashkov, A. A.
Kon’kov, V. V.
Novak, J.
Tseilikman, O. B.
 
Тематика ANXIETY
BRAIN-DERIVED NEUROTROPHIC FACTOR
DOPAMINE
FREEZING
MONOAMINES OXIDIZE-A
PTSD
RESVERATROL
SEROTONIN
BRAIN DERIVED NEUROTROPHIC FACTOR
CATECHOL METHYLTRANSFERASE
DOPAMINE
MESSENGER RNA
MONOAMINE
RESVERATROL
SEROTONIN
AMINE
BRAIN DERIVED NEUROTROPHIC FACTOR
RESVERATROL
ANIMAL BEHAVIOR
ANIMAL EXPERIMENT
ANIMAL MODEL
ANXIETY DISORDER
ARTICLE
CHEESE
CONTROLLED STUDY
DIET SUPPLEMENTATION
DIETARY INTAKE
ELEVATED PLUS MAZE TEST
ENZYME ACTIVITY
GENE EXPRESSION
HIPPOCAMPUS
MALE
MONOAMINE METABOLISM
NONHUMAN
PHENOTYPE
POSTTRAUMATIC STRESS DISORDER
PROTEIN EXPRESSION
RAT
SEROTONIN METABOLISM
ANIMAL
DIETARY SUPPLEMENT
GENETICS
AMINES
ANIMALS
BRAIN-DERIVED NEUROTROPHIC FACTOR
CHEESE
DIETARY SUPPLEMENTS
RATS
RESVERATROL
STRESS DISORDERS, POST-TRAUMATIC
 
Описание Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD. © 2023 by the authors.
23-15-20040; Russian Science Foundation, RSF
This work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040).
 
Дата 2024-04-05T16:33:34Z
2024-04-05T16:33:34Z
2023
 
Тип Article
Journal article (info:eu-repo/semantics/article)
|info:eu-repo/semantics/publishedVersion
 
Идентификатор Tseilikman, V, Shatilov, VA, Zhukov, MS, Buksha, IA, Epitashvily, AE, Lipatov, IA, Aristov, MR, Koshelev, AG, Karpenko, M, Traktirov, DS, Maistrenko, VA, Kamel, M, Buhler, A, Kovaleva, E, Kalinina, TS, Pashkov, AA, Kon’kov, VV, Novak, J & Tseilikman, O 2023, 'Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation', International Journal of Molecular Sciences, Том. 24, № 18, 14343. https://doi.org/10.3390/ijms241814343
Tseilikman, V., Shatilov, V. A., Zhukov, M. S., Buksha, I. A., Epitashvily, A. E., Lipatov, I. A., Aristov, M. R., Koshelev, A. G., Karpenko, M., Traktirov, D. S., Maistrenko, V. A., Kamel, M., Buhler, A., Kovaleva, E., Kalinina, T. S., Pashkov, A. A., Kon’kov, V. V., Novak, J., & Tseilikman, O. (2023). Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation. International Journal of Molecular Sciences, 24(18), [14343]. https://doi.org/10.3390/ijms241814343
1661-6596
Final
All Open Access, Gold, Green
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172768878&doi=10.3390%2fijms241814343&partnerID=40&md5=03924fe855f7bfbff35744131c94819a
https://www.mdpi.com/1422-0067/24/18/14343/pdf?version=1695207406
http://elar.urfu.ru/handle/10995/130821
10.3390/ijms241814343
85172768878
001074050800001
 
Язык en
 
Связанные ресурсы info:eu-repo/grantAgreement/RSF//23-15-20040
 
Права Open access (info:eu-repo/semantics/openAccess)
cc-by
https://creativecommons.org/licenses/by/4.0/
 
Формат application/pdf
 
Издатель Multidisciplinary Digital Publishing Institute (MDPI)
 
Источник International Journal of Molecular Sciences
International Journal of Molecular Sciences