Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey
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| Автор |
Shahid, H.
Shah, A. A. Shah, Bukhari, S. N. U. Naqvi, A. Z. Arooj, I. Javeed, M. Aslam, M. Chandio, A. D. Farooq, M. Gilani, S. J. Bin, Jumah, M. N. |
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| Тематика |
ANTIBACTERIAL ACTIVITY
FE2O3-NPS GREEN SYNTHESIS HONEY MEDIATION |
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| Описание |
Green approaches for nanoparticle synthesis have emerged as biocompatible, economical, and environment-friendly alternatives to counteract the menace of microbial drug resistance. Recently, the utilization of honey as a green source to synthesize Fe2O3-NPs has been introduced, but its antibacterial activity against one of the opportunistic MDR pathogens, Klebsiella pneumoniae, has not been explored. Therefore, this study employed Apis mellifera honey as a reducing and capping agent for the synthesis of iron oxide nanoparticles (Fe2O3-NPs). Subsequent to the characterization of nanoparticles, their antibacterial, antioxidant, and anti-inflammatory properties were appraised. In UV-Vis spectroscopic analysis, the absorption band ascribed to the SPR peak was observed at 350 nm. XRD analysis confirmed the crystalline nature of Fe2O3-NPs, and the crystal size was deduced to be 36.2 nm. Elemental analysis by EDX validated the presence of iron coupled with oxygen in the nanoparticle composition. In ICP-MS, the highest concentration was of iron (87.15 ppm), followed by sodium (1.49 ppm) and other trace elements (<1 ppm). VSM analysis revealed weak magnetic properties of Fe2O3-NPs. Morphological properties of Fe2O3-NPs revealed by SEM demonstrated that their average size range was 100–150 nm with a non-uniform spherical shape. The antibacterial activity of Fe2O3-NPs was ascertained against 30 clinical isolates of Klebsiella pneumoniae, with the largest inhibition zone recorded being 10 mm. The MIC value for Fe2O3-NPs was 30 µg/mL. However, when mingled with three selected antibiotics, Fe2O3-NPs did not affect any antibacterial activity. Momentous antioxidant (IC50 = 22 µg/mL) and anti-inflammatory (IC50 = 70 µg/mL) activities of Fe2O3-NPs were discerned in comparison with the standard at various concentrations. Consequently, honey-mediated Fe2O3-NP synthesis may serve as a substitute for orthodox antimicrobial drugs and may be explored for prospective biomedical applications. © 2023 by the authors.
Princess Nourah Bint Abdulrahman University, PNU: PNURSP2023R108 This research project was supported by the Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R108), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. |
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| Дата |
2024-04-05T16:33:45Z
2024-04-05T16:33:45Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Shahid, H, Shah, AA, Uddin Shah Bukhari, SN, Naqvi, AZ, Arooj, I, Javeed, M, Aslam, M, Chandio, AD, Farooq, M, Gilani, SJ & Jumah, MNB 2023, 'Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey', Molecules, Том. 28, № 18, 6504. https://doi.org/10.3390/molecules28186504
Shahid, H., Shah, A. A., Uddin Shah Bukhari, S. N., Naqvi, A. Z., Arooj, I., Javeed, M., Aslam, M., Chandio, A. D., Farooq, M., Gilani, S. J., & Jumah, M. N. B. (2023). Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey. Molecules, 28(18), [6504]. https://doi.org/10.3390/molecules28186504 1420-3049 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172777432&doi=10.3390%2fmolecules28186504&partnerID=40&md5=2675ae0b3859a150e9b877ada290b629 https://www.mdpi.com/1420-3049/28/18/6504/pdf?version=1694096439 http://elar.urfu.ru/handle/10995/130826 10.3390/molecules28186504 85172777432 001073974400001 |
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en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
Molecules
Molecules |
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