Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts
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| Автор |
Rykunova, E. B.
Mikeladze, M. A. Utepova, I. A. Chupakhin, O. N. Guzhova, I. V. Lazarev, V. F. |
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| Тематика |
CEREBROSPINAL FLUID
CHAPERONES HSP70 PYRROLYLAZINE AND INDOLYLAZINE DERIVATIVES SECONDARY INJURIES TRAUMATIC BRAIN INJURY ANIMAL BRAIN INJURY CEREBROSPINAL FLUID COMPLICATION NERVE CELL RAT TRAUMATIC BRAIN INJURY ANIMALS BRAIN INJURIES BRAIN INJURIES, TRAUMATIC NEURONS RATS |
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| Описание |
Abstract: The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolylazines and indolylazines, which have neuroprotective properties. © 2023, The Author(s).
Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2021-683; Russian Science Foundation, RSF: 18-74-10087 This work was supported by the Russian Science Foundation, project no. 18-74-10087. Rat embryonic fibroblasts DFK-3 were obtained from the Vertebrate Cell Culture Collection core facility, which was supported by a grant from the Ministry of Education and Science of the Russian Federation (agreement no. 075-15-2021-683). Cells were cultured in DMEM medium (BioloT, Russia) supplemented with 10% fetal bovine serum (Gibco, United States) and antibiotics penicillin 100 units/mL and streptomycin 0.1 mg/mL (BioloT, Russia) at 37°C and 5% CO. 2 |
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| Дата |
2024-04-05T16:34:26Z
2024-04-05T16:34:26Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Rykunova, EB, Mikeladze, MA, Utepova, IA, Chupakhin, ON, Guzhova, IV & Lazarev, VF 2023, 'Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts', Doklady Biochemistry and Biophysics, Том. 511, № 1, стр. 235-239. https://doi.org/10.1134/S1607672923700345
Rykunova, E. B., Mikeladze, M. A., Utepova, I. A., Chupakhin, O. N., Guzhova, I. V., & Lazarev, V. F. (2023). Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts. Doklady Biochemistry and Biophysics, 511(1), 235-239. https://doi.org/10.1134/S1607672923700345 1607-6729 Final All Open Access, Hybrid Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174015731&doi=10.1134%2fS1607672923700345&partnerID=40&md5=63f8eb6dcbbf48077cd5ce88f51191c7 https://link.springer.com/content/pdf/10.1134/S1607672923700345.pdf http://elar.urfu.ru/handle/10995/130854 10.1134/S1607672923700345 85174015731 001086576900015 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//18-74-10087
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Pleiades Publishing
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| Источник |
Doklady Biochemistry and Biophysics
Doklady Biochemistry and Biophysics |
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