Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action
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| Автор |
Grzhegorzhevskii, K.
Tonkushina, M. Gushchin, P. Gagarin, I. Ermoshin, A. Belova, K. Prokofyeva, A. Ostroushko, A. Novikov, A. |
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| Тематика |
ANTIBIOTIC ACTION
KEPLERATE POLYOXOMETALATE TETRACYCLINE VIBRATIONAL SPECTROSCOPY |
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| Описание |
The association process between the tetracycline (TC) antibiotic molecule and Keplerate-type nanocluster polyoxometalate (POM) {Mo72Fe30} was studied in aqueous solution. The novel supramolecular ensemble {Mo72Fe30}@TC12.5 was produced, its composition and structure were revealed by means of elemental analysis (C, N, H) and vibrational spectroscopy (IR and Raman). Based on the spectral data, the POM structure’s integrity was confirmed and binding sites of TC with the Keplerate {Mo72Fe30} surface were found. Due to thermogravimetric analysis (TG) and in-situ Raman spectroscopy during the process of {Mo72Fe30}@TC12.5 thermal destruction, we showed a significant change in the phase composition of POM’s destruction products after association with TC. The antibacterial activity of the obtained complex {Mo72Fe30}@TC12.5 was examined. The experimental results allowed us to note the partial inhibition of TC’s antibacterial activity owing to the coordination of TC to FeIII centers, in turn, which hinders the participation of TC in coordination via Mg2+ of ribosomal subunits 30S in bacteria. © 2022 by the authors.
Ministry of Education and Science of the Russian Federation, Minobrnauka The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged. |
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| Дата |
2024-04-05T16:34:41Z
2024-04-05T16:34:41Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Grzhegorzhevskii, K, Tonkushina, M, Gushchin, P, Gagarin, I, Ermoshin, A, Belova, K, Prokofyeva, A, Ostroushko, A & Novikov, A 2023, 'Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action', Inorganics, Том. 11, № 1, 9. https://doi.org/10.3390/inorganics11010009
Grzhegorzhevskii, K., Tonkushina, M., Gushchin, P., Gagarin, I., Ermoshin, A., Belova, K., Prokofyeva, A., Ostroushko, A., & Novikov, A. (2023). Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action. Inorganics, 11(1), [9]. https://doi.org/10.3390/inorganics11010009 2304-6740 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146663805&doi=10.3390%2finorganics11010009&partnerID=40&md5=941c9cf6c51c50d42a129b2262fb825b https://www.mdpi.com/2304-6740/11/1/9/pdf?version=1671956450 http://elar.urfu.ru/handle/10995/130870 10.3390/inorganics11010009 85146663805 000914889100001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Inorganics
Inorganics |
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