JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
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| Автор |
Sarapultsev, A.
Gusev, E. Komelkova, M. Utepova, I. Luo, S. Hu, D. |
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| Тематика |
INFLAMMATION
JAK INHIBITORS JAK-STAT SIGNALING NEUROPSYCHIATRIC DISORDERS STRESS-RELATED CONDITIONS THERAPEUTIC ADVANCEMENTS |
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| Описание |
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathway can lead to severe immunodeficiencies and malignancies, and its role extends to neurotransduction and pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological and inflammatory disorders, their application has generally been limited to diseases with similar pathogenic features. Despite the modest expression of JAK-STAT in the CNS, it is crucial for functions in the cortex, hippocampus, and cerebellum, making it relevant in conditions like Parkinson's disease and other neuroinflammatory disorders. Furthermore, the influence of the pathway on serotonin receptors and phospholipase C has implications for stress and mood disorders. This review expands the understanding of JAK-STAT, moving beyond traditional immunological contexts to explore its role in stress-related disorders and CNS function. Recent findings, such as the effectiveness of Jakinibs in chronic conditions such as rheumatoid arthritis, expand their therapeutic applicability. Advances in isoform-specific inhibitors, including filgotinib and upadacitinib, promise greater specificity with fewer off-target effects. Combination therapies, involving Jakinibs and monoclonal antibodies, aiming to enhance therapeutic specificity and efficacy also give great hope. Overall, this review bridges the gap between basic science and clinical application, elucidating the complex influence of the JAK-STAT pathway on human health and guiding future interventions. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).
122020900136–4, FENU-2023–0014 This work was funded by South Ural State University, scientific theme No. FENU-2023–0014 and partly by the theme 122020900136–4 of Institute of Immunology and Physiology. |
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| Дата |
2024-04-05T16:35:39Z
2024-04-05T16:35:39Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Sarapultsev, A, Gusev, E, Komelkova, M, Utepova, I, Luo, S & Hu, D 2023, 'JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions', Molecular Biomedicine, Том. 4, № 1, 40. https://doi.org/10.1186/s43556-023-00151-1
Sarapultsev, A., Gusev, E., Komelkova, M., Utepova, I., Luo, S., & Hu, D. (2023). JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. Molecular Biomedicine, 4(1), [40]. https://doi.org/10.1186/s43556-023-00151-1 2662-8651 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175985223&doi=10.1186%2fs43556-023-00151-1&partnerID=40&md5=486327fc6e2aed343e57b008e64e9daf https://link.springer.com/content/pdf/10.1186/s43556-023-00151-1.pdf http://elar.urfu.ru/handle/10995/130934 10.1186/s43556-023-00151-1 85175985223 001097190400001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Springer
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| Источник |
Molecular Biomedicine
Molecular Biomedicine |
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