Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line
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| Автор |
Antosyuk, O. N.
Gorskaya, A. V. Petrovskii, D. V. Dubatolova, T. D. |
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| Тематика |
ACETYLSALICYLIC ACID
C57BL / 6J MICE CHROMOSOMAL ABERRATIONS CYTOGENETIC TOXICITY ETOPOSIDE PROTECTIVE PROPERTIES ACETYLSALICYLIC ACID ETOPOSIDE ANIMAL EXPERIMENT ARTICLE CHROMOSOME ABERRATION CHROMOSOME ANALYSIS CYTOGENETICS DRUG EXPOSURE METAPHASE MOUSE NONHUMAN |
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| Описание |
The paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice. The cytogenetic activity and protective properties assessment was carried out using the chromosome aberration analysis in metaphase cells. Etoposide was tested at a concentration of 15 and 3 mg/kg and aspirin — at a concentration of 25 mg/kg of the animal. The results of metaphase analysis showed that etoposide exhibits cytogenetic toxicity in both doses, and aspirin exhibits protective properties against the toxicity of etoposide at a concentration of 15 mg/kg. The results of chromosome analysis regarding the protective properties of aspirin against etoposide at a concentration of 3 mg/kg are ambiguous and require further experiments. © Team of Authors, 2023.
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| Дата |
2024-04-05T16:35:47Z
2024-04-05T16:35:47Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Антосюк, ОН, Горская, АВ, Петровский, ДВ & Дубатолова, ТД 2023, 'Изучение токсического проявления этопозида при сопутствующем воздействии ацетилсалициловой кислотой в качестве протектора на примере мышей линии C57Bl/6J', Антибиотики и химиотерапия, Том. 68, № 5-6, стр. 33-38. https://doi.org/10.37489/0235-2990-2023-68-5-6-33-38
Антосюк, О. Н., Горская, А. В., Петровский, Д. В., & Дубатолова, Т. Д. (2023). Изучение токсического проявления этопозида при сопутствующем воздействии ацетилсалициловой кислотой в качестве протектора на примере мышей линии C57Bl/6J. Антибиотики и химиотерапия, 68(5-6), 33-38. https://doi.org/10.37489/0235-2990-2023-68-5-6-33-38 0235-2990 Final All Open Access, Hybrid Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176292320&doi=10.37489%2f0235-2990-2023-68-5-6-33-38&partnerID=40&md5=c915c0f3813f5c1f43fc31c9156f0efb https://www.antibiotics-chemotherapy.ru/jour/article/download/1047/919 http://elar.urfu.ru/handle/10995/130940 54704060 10.37489/0235-2990-2023-68-5-6-33-38 85176292320 |
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| Язык |
ru
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Publishing House OKI
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| Источник |
Antibiotics and Chemotherapy
Antibiotiki i Khimioterapiya |
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