Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides
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| Автор |
Krasnov, V. P.
Nizova, I. A. Vigorov, A. Y. Matveeva, T. V. Levit, G. L. Kodess, M. I. Ezhikova, M. A. Slepukhin, P. A. Bakulin, D. A. Tyurenkov, I. N. Charushin, V. N. |
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| Тематика |
5-OXOPROLINE
AMIDES HISTIDINE IN VIVO EXPERIMENTS MORPHOLINE PEPTIDES PHENYLALANINE PIPERIDINE PYROGLUTAMIC ACID AMIDE ANTITHROMBOCYTIC AGENT FIBRINOLYTIC AGENT PEPTIDE PYROGLUTAMIC ACID AGED CHEMISTRY HUMAN THROMBOSIS AGED AMIDES FIBRINOLYTIC AGENTS HUMANS PEPTIDES PLATELET AGGREGATION INHIBITORS PYRROLIDONECARBOXYLIC ACID THROMBOSIS |
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| Описание |
Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases. Thus, there is a need to study new therapeutic strategies, including new medicinal agents for the efficient and safe correction of thrombus disorders. In this work, we have synthesized a number of new amides and peptides of 4-amino-5-oxoprolines and studied their antiplatelet and antithrombotic activity in experiments in vitro and in vivo. It has been found that the newly obtained compounds slow down the process of thrombus formation in a model of arterial and venous thrombosis, without affecting plasma hemostasis parameters. (2S,4S)-4-Amino-1-(4-fluorophenyl)-5-oxoprolyl-(S)-phenylalanine proved to be the most efficient among the studied derivatives. The results obtained indicate the advisability of further studies on 5-oxoproline derivatives in order to design pharmaceutical agents for the prevention and treatment of the consequences of thrombosis. © 2023 by the authors.
Ministry of Science and Higher Education of the Russian Federation: 075-15-2020-777 This research was funded by the Ministry of Science and Higher Education of Russia (agreement no. 075-15-2020-777 of 1 October 2020). |
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| Дата |
2024-04-05T16:36:34Z
2024-04-05T16:36:34Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Krasnov, V, Nizova, I, Vigorov, A, Matveeva, T, Levit, G, Kodess, M, Ezhikova, M, Slepukhin, P, Bakulin, D, Tyurenkov, I & Charushin, V 2023, 'Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides', Molecules, Том. 28, № 21, 7401. https://doi.org/10.3390/molecules28217401
Krasnov, V., Nizova, I., Vigorov, A., Matveeva, T., Levit, G., Kodess, M., Ezhikova, M., Slepukhin, P., Bakulin, D., Tyurenkov, I., & Charushin, V. (2023). Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides. Molecules, 28(21), [7401]. https://doi.org/10.3390/molecules28217401 1420-3049 Final All Open Access, Gold, Green https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176608417&doi=10.3390%2fmolecules28217401&partnerID=40&md5=52faeb3a24c5a45fe6a0f264f3a46c60 https://www.mdpi.com/1420-3049/28/21/7401/pdf?version=1698979636 http://elar.urfu.ru/handle/10995/130967 10.3390/molecules28217401 85176608417 001099550100001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
Molecules
Molecules |
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