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Structural and Morphological Features of Anisotropic Chitosan Hydrogels Obtained by Ion-Induced Neutralization in a Triethanolamine Medium

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Заглавие Structural and Morphological Features of Anisotropic Chitosan Hydrogels Obtained by Ion-Induced Neutralization in a Triethanolamine Medium
 
Автор Shmakov, S. L.
Babicheva, T. S.
Kurochkina, V. A.
Lugovitskaya, T. N.
Shipovskaya, A. B.
 
Тематика ANISOTROPIC HYDROGELS
BIOCOMPATIBLE POLYMERS
CHITOSAN
GLYCOLIC ACID
LIESEGANG STRUCTURES
TRIETHANOLAMINE
 
Описание For the first time, anisotropic hydrogel material with a highly oriented structure was obtained by the chemical reaction of polymer-analogous transformation of chitosan glycolate—chitosan base using triethanolamine (TEA) as a neutralizing reagent. Tangential bands or concentric rings, depending on the reaction conditions, represent the structural anisotropy of the hydrogel. The formation kinetics and the ratio of the positions of these periodic structures are described by the Liesegang regularities. Detailed information about the bands is given (formation time, coordinate, width, height, and formation rate). The supramolecular ordering anisotropy of the resulting material was evaluated both by the number of Liesegang bands (up to 16) and by the average values of the TEA diffusion coefficient ((15–153) × 10−10 and (4–33) × 10−10 m2/s), corresponding to the initial and final phase of the experiment, respectively. The minimum chitosan concentration required to form a spatial gel network and, accordingly, a layered anisotropic structure was estimated as 1.5 g/dL. Morphological features of the structural anisotropic ordering of chitosan Liesegang structures are visualized by scanning electron microscopy. The hemocompatibility of the material obtained was tested, and its high sorption–desorption properties were evaluated using the example of loading–release of cholecalciferol (loading degree ~35–45%, 100% desorption within 25–28 h), which was observed for a hydrophobic substance inside a chitosan-based material for the first time. © 2023 by the authors.
Russian Science Foundation, RSF: 22-23-00320
The study was supported by a grant from the Russian Science Foundation № 22-23-00320, https://rscf.ru/project/22-23-00320/, accessed on 3 November 2023.
 
Дата 2024-04-05T16:36:58Z
2024-04-05T16:36:58Z
2023
 
Тип Article
Journal article (info:eu-repo/semantics/article)
|info:eu-repo/semantics/publishedVersion
 
Идентификатор Shmakov, SL, Babicheva, TS, Kurochkina, VA, Lugovitskaya, TN & Shipovskaya, AB 2023, 'Structural and Morphological Features of Anisotropic Chitosan Hydrogels Obtained by Ion-Induced Neutralization in a Triethanolamine Medium', Gels, Том. 9, № 11, 876. https://doi.org/10.3390/gels9110876
Shmakov, S. L., Babicheva, T. S., Kurochkina, V. A., Lugovitskaya, T. N., & Shipovskaya, A. B. (2023). Structural and Morphological Features of Anisotropic Chitosan Hydrogels Obtained by Ion-Induced Neutralization in a Triethanolamine Medium. Gels, 9(11), [876]. https://doi.org/10.3390/gels9110876
2310-2861
Final
All Open Access, Gold, Green
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178120581&doi=10.3390%2fgels9110876&partnerID=40&md5=20c6c20a43ce2b2f8692ea168be8532e
https://www.mdpi.com/2310-2861/9/11/876/pdf?version=1699093361
http://elar.urfu.ru/handle/10995/131000
10.3390/gels9110876
85178120581
001114639500001
 
Язык en
 
Связанные ресурсы info:eu-repo/grantAgreement/RSF//22-23-00320
 
Права Open access (info:eu-repo/semantics/openAccess)
cc-by
https://creativecommons.org/licenses/by/4.0/
 
Формат application/pdf
 
Издатель Multidisciplinary Digital Publishing Institute (MDPI)
 
Источник Gels
Gels