Investigation of the Penetration Ability of InP/ZnSe/ZnS 650 Quantum Dots into the Anterior Chamber of the Eye by Topical Application. Experimental Study
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Investigation of the Penetration Ability of InP/ZnSe/ZnS 650 Quantum Dots into the Anterior Chamber of the Eye by Topical Application. Experimental Study
|
|
| Автор |
Shilovskikh, O. V.
Ponomarev, V. O. Kazaikin, V. N. Tkachenko, K. A. Kovalenko, E. G. Vokhmintsev, A. S. Vainshtein, I. A. Kuznetsova, Y. V. |
|
| Тематика |
CORNEA
PENETRATING ABILITY QUANTUM DOTS TOPICAL APPLICATION INDIUM PHOSPHIDE NANOPARTICLE QUANTUM DOT UNCLASSIFIED DRUG ZINC SELENIDE NANOPARTICLE ZINC SULFIDE NANOPARTICLE ANIMAL EXPERIMENT ANTERIOR EYE CHAMBER ARTICLE CONTROLLED STUDY CORNEA DRUG PENETRATION EPITHELIZATION EXPERIMENTAL RABBIT EXPERIMENTAL STUDY MOISTURE NONHUMAN SPECTROPHOTOMETRY TOPICAL TREATMENT |
|
| Описание |
In connection with the problem of formation of strains of pathogenic microflora resistant to antibacterial drugs, research on the use of nanoparticles, namely quantum dots, has been actively conducted recently. Quantum dots can be used as an anti-infective agent, a means for visualization of intraocular structures, drug delivery, as well as a means for electrical stimulation of the retina. Successful application of quantum dots as an anti-infective agent necessitates the study of their penetrating ability into the anterior chamber. The aim of the study was to experimentally investigate the penetration ability of InP/ZnSe/ZnS 650 QDs in the anterior chamber of the eye at topical application. The object of the study was InP/ZnSe/ZnS 650 quantum dots. The study was carried out on laboratory rabbits (#6), which were divided randomly in pairs into groups. In rabbits #1 and #2 the eyes remained intact, #3 and #4 - a bandage soft contact lens was placed on the cornea of the right eye, #5 and #6 the cornea of the right eye was de-epithelialized. All experimental rabbits during the day 6 times instillation of 10 % solution of InP/ZnSe/ZnS 650 quantum dots was performed, and at the end 0.2 ml of moisture was taken from the anterior chamber of the right eye. The left eyes in all individuals were the control group. Identification of quantum dots into the anterior chamber was performed using a highly sensitive spectrophotometer UV-3600 (Shimadzu). The experimental study of the ability of InP/ZnSe/ZnS 650 quantum dots at topical application to penetrate into the intraocular cavity by the claimed detection methods did not allow their detection in the anterior chamber moisture even in minimal concentration. © 2023 Ophthalmology Publishing Group. All rights reserved.
|
|
| Дата |
2024-04-05T16:38:56Z
2024-04-05T16:38:56Z 2023 |
|
| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
|
| Идентификатор |
Shilovskikh, OV, Ponomarev, VO, Kazaykin, VN, Tkachenko, KA, Kovalenko, EG, Vokhmintsev, AS, Weinstein, IA & Kuznetsova, YV 2023, 'Исследование проникающей способности квантовых точек InP/ZnSe/ZnS 650 в переднюю камеру глаза при топическом применении. Экспериментальное исследование', Офтальмология, Том. 20, № 4, стр. 743-752. https://doi.org/10.18008/1816-5095-2023-4-743-752
Shilovskikh, O. V., Ponomarev, V. O., Kazaykin, V. N., Tkachenko, K. A., Kovalenko, E. G., Vokhmintsev, A. S., Weinstein, I. A., & Kuznetsova, Y. V. (2023). Исследование проникающей способности квантовых точек InP/ZnSe/ZnS 650 в переднюю камеру глаза при топическом применении. Экспериментальное исследование. Офтальмология, 20(4), 743-752. https://doi.org/10.18008/1816-5095-2023-4-743-752 1816-5095 Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181915340&doi=10.18008%2f1816-5095-2023-4-743-752&partnerID=40&md5=a7492809fe7830aafb5519506ac27077 https://www.ophthalmojournal.com/opht/article/download/2246/1172 http://elar.urfu.ru/handle/10995/131113 57134647 10.18008/1816-5095-2023-4-743-752 85181915340 |
|
| Язык |
ru
|
|
| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
|
| Формат |
application/pdf
|
|
| Издатель |
Ophthalmology Publishing Group
|
|
| Источник |
Ophthalmology in Russia
Oftalmologiya |
|