The Development of Tablets containing Vinpocetine and Ginkgo biloba L. Extract
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
The Development of Tablets containing Vinpocetine and Ginkgo biloba L. Extract
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| Автор |
Slovesnova, N. V.
Petrov, A. Y. Glavatskih, S. А. Bolotova, А. V. Kopchuk, D. S. |
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| Тематика |
DISINTEGRATION TEST
DISSOLUTION TEST GINKGO BILOBA L. EXTRACT VINPOCETINE CROSPOVIDONE EUDRAGIT GINKGO BILOBA EXTRACT HYDROXYPROPYLCELLULOSE HYDROXYPROPYLMETHYLCELLULOSE MICROCRYSTALLINE CELLULOSE POLYSORBATE 80 STARCH SULPIRIDE TERPENE VINPOCETINE ANALYTICAL PARAMETERS ANGLE OF REPOSE ANIMAL EXPERIMENT ANIMAL MODEL ANIMAL TISSUE ARTICLE BIOAVAILABILITY BULK DENSITY CALIBRATION CONTROLLED STUDY DISSOLUTION DRUG DOSAGE FORM DRUG FORMULATION DRUG GRANULATION DRUG RELEASE DRUG SOLUBILITY EXCIPIENT COMPATIBILITY HAUSNER RATIO MALE MATHEMATICAL MODEL NONHUMAN PROGRESSION FREE SURVIVAL SCANNING ELECTRON MICROSCOPY SURFACE PROPERTY TABLET TABLET COMPRESSION TABLET DISINTEGRATION TABLET DISINTEGRATION TIME TABLET FRIABILITY TABLET HARDNESS TABLET THICKNESS TAPPED DENSITY TEMPERATURE TERAHERTZ SPECTROSCOPY VISCOSITY WETTABILITY |
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| Описание |
The release rate of active pharmaceutical ingredients (APIs) from tablet dosage forms is significantly influenced by the composition of the formulation, in particular filler composition. In this work, we analyzed the impact of the ratio of excipients on the release rate of vinpocetine from a tablet containing Ginkgo biloba L. extract as the second API. Microcrystalline cellulose (MCC), hydroxypropylcellulose (L-HPC) mixed with MCC (up to 16% of HPC), and partially pregelatinized starch were used in different ratios as excipients. Moreover, tween-80 was used to study the effect of introduction of emulsifier on the APIs’ release rates. According to our findings, optimal APIs’ release rates are achieved when using the combination of MCC with HPC at a ratio of 2:3. © 2023, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.
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| Дата |
2024-04-05T16:39:33Z
2024-04-05T16:39:33Z 2023 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Slovesnova, N, Petrov, A, Glavatskih, S, Bolotova, АV & Kopchuk, D 2023, 'The Development of Tablets containing Vinpocetine and Ginkgo biloba L. Extract', International Journal of Drug Delivery Technology, Том. 13, № 04, стр. 1139-1144. https://doi.org/10.25258/ijddt.13.4.02
Slovesnova, N., Petrov, A., Glavatskih, S., Bolotova, А. V., & Kopchuk, D. (2023). The Development of Tablets containing Vinpocetine and Ginkgo biloba L. Extract. International Journal of Drug Delivery Technology, 13(04), 1139-1144. https://doi.org/10.25258/ijddt.13.4.02 0975-4415 Final All Open Access, Bronze https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185682800&doi=10.25258%2fijddt.13.4.02&partnerID=40&md5=d31173e87668e7ea7a55fc133970caa0 https://doi.org/10.25258/ijddt.13.4.02 http://elar.urfu.ru/handle/10995/131162 10.25258/ijddt.13.4.02 85185682800 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
Dr. Yashwant Research Labs Pvt. Ltd.
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| Источник |
INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY
International Journal of Drug Delivery Technology |
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