4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application
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| Автор |
Fedin, V. V.
Obydennov, D. L. Usachev, S. A. Sosnovskikh, V. Y. |
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| Тематика |
2-PYRONE
4-HYDROXY-2-PYRONE 4-PYRONE BIOLOGICAL ACTIVITY CYCLIZATION KETENE KETOACETYLENE NATURAL PRODUCTS POLYKETIDE TRIACETIC ACID LACTONE |
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| Описание |
4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed. © 2023 by the authors.
Russian Science Foundation, RSF: 22-73-10236 This work was financially supported by the Russian Science Foundation (grant 22-73-10236, https://rscf.ru/project/22-73-10236/(accessed on 10 December 2023)). |
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| Дата |
2024-04-05T16:39:36Z
2024-04-05T16:39:36Z 2023 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) |info:eu-repo/semantics/publishedVersion |
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| Идентификатор |
Fedin, V, Obydennov, D, Usachev, S & Sosnovskikh, V 2023, '4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application', Organics, Том. 4, № 4, стр. 539-561. https://doi.org/10.3390/org4040037
Fedin, V., Obydennov, D., Usachev, S., & Sosnovskikh, V. (2023). 4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application. Organics, 4(4), 539-561. https://doi.org/10.3390/org4040037 2673-401X Final All Open Access, Gold https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185691563&doi=10.3390%2forg4040037&partnerID=40&md5=ae8522d732e01221e5bd8ecfdc726db5 https://www.mdpi.com/2673-401X/4/4/37/pdf?version=1702705703 http://elar.urfu.ru/handle/10995/131163 10.3390/org4040037 85185691563 001130919800001 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//22-73-10236
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Multidisciplinary Digital Publishing Institute (MDPI)
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| Источник |
Organics
Organics |
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