Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment
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| Автор |
Zakaly, H. M. H.
Mostafa, M. Y. A. Zhukovsky, M. |
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| Тематика |
177LU
BONE METASTASIS METHYLENE DIPHOSPHONATE (MDP) PALLIATIVE THERAPY RADIONUCLIDE THERAPY RADIOPHARMACEUTICAL LANTHANIDE LUTETIUM 177 MEDRONIC ACID RADIOISOTOPE RADIOPHARMACEUTICAL AGENT ARTICLE BIOKINETIC MODEL BONE METASTASIS IONIZING RADIATION KINETICS PALLIATIVE THERAPY RADIATION PROTECTION RADIOCHEMISTRY |
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| Описание |
177Lu is a lanthanide radionuclide. In recent years, the possibility of applying a drug based on the177Lu radionuclide as a palliative treatment for bone metastases has increased.177Lu has many prospects in terms of its applications in nuclear medicine. The high-energy beta particles and the relatively short half-life of the radionuclide are used to provide an effective treatment. In this work, a comparison of organ and tissue doses is performed with two different drugs:177Lu in an ionic radionuclide form and177Lu labeled methylene diphosphonate (177Lu-MDP).177Lu in an ionic form actively accumulates in the liver and bones. Phosphonate compounds form stable radio-labeled complexes. This suggests that177Lu-MDP is a non-dissociated form of the drug. The distribution and elimination of the drug occur according to the kinetics of the carrier, i.e., methylene diphosphonate. It is shown that the use of an osteotropic complex (describing any drug that is attracted to and targets bone) allows for the concentration of a large dose in pathological areas and minimizes damage to healthy organs and tissues. © 2022, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.
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| Дата |
2024-04-08T11:05:51Z
2024-04-08T11:05:51Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Zakaly, HMH, Mostafa, MYA & Zhukovsky, M 2022, 'Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment', International Journal of Drug Delivery Technology, Том. 12, № 4, стр. 1802-1807. https://doi.org/10.25258/ijddt.12.4.52
Zakaly, H. MH., Mostafa, M. YA., & Zhukovsky, M. (2022). Biokinetic Model Development of177Lu-labeled Methylene Diphosphonate as a Radiopharmaceutical Treatment. International Journal of Drug Delivery Technology, 12(4), 1802-1807. https://doi.org/10.25258/ijddt.12.4.52 0975-4415 Final All Open Access; Bronze Open Access https://doi.org/10.25258/ijddt.12.4.52 https://doi.org/10.25258/ijddt.12.4.52 http://elar.urfu.ru/handle/10995/131221 10.25258/ijddt.12.4.52 85145924875 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
Dr. Yashwant Research Labs Pvt. Ltd.
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| Источник |
INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY
International Journal of Drug Delivery Technology |
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