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Carborane-Containing Folic Acid bis-Amides: Synthesis and In Vitro Evaluation of Novel Promising Agents for Boron Delivery to Tumour Cells

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Заглавие Carborane-Containing Folic Acid bis-Amides: Synthesis and In Vitro Evaluation of Novel Promising Agents for Boron Delivery to Tumour Cells
 
Автор Gruzdev, D. A.
Telegina, A. A.
Levit, G. L.
Solovieva, O. I.
Gusel’nikova, T. Y.
Razumov, I. A.
Krasnov, V. P.
Charushin, V. N.
 
Тематика AMIDES
BNCT
BORON ACCUMULATION
CARBORANES
CYTOTOXICITY
FOLIC ACID
MTT ASSAY
TUMOUR CELLS
AMIDES
BORON
FOLIC ACID
GLIOBLASTOMA
HUMANS
THINNESS
2 [[4 [[(2 AMINO 4 HYDROXYPTERIDIN 6 YL)METHYL]AMINO]PHENYL] FORMAMIDO] N 1 N 5 BIS [2 [(7,8 DICARBA NIDO UNDECARBORAN 3 YL)AMINOCARBONYL]PENTYL]PENTANEDIAMIDE
2 [[4 [[(2 AMINO 4 HYDROXYPTERIDIN 6 YL)METHYL]AMINO]PHENYL] FORMAMIDO] N 1 N 5 BIS [2 [(7,8 DICARBA NIDO UNDECARBORAN 7 YL)ACETYLAMINO]ETHYL]PENTANEDIAMIDE SEMIHYDRATE
2 [[4 [[(2 AMINO 4 HYDROXYPTERIDIN 6 YL)METHYL]AMINO]PHENYL] FORMAMIDO] N 1 N 5 BIS [5 [(1,2 DICARBA CLOSO DODECARBORAN 3 YL)AMINOCARBONYL]PENTYL]PENTANEDIAMIDE
AMIDE
BORON DERIVATIVE
CARBORANE DERIVATIVE
CISPLATIN
FOLIC ACID DERIVATIVE
UNCLASSIFIED DRUG
AMIDE
BORON
FOLIC ACID
NIDO-CARBORANE
ARTICLE
BORON NEUTRON CAPTURE THERAPY
CELL VIABILITY
CONTROLLED STUDY
CYTOTOXICITY
DRUG SYNTHESIS
DU145 CELL LINE
ELEMENTAL ANALYSIS
FEMALE
GLIOBLASTOMA
HUMAN
HUMAN CELL
IN VITRO STUDY
MALE
MDA-MB-231 CELL LINE
MTT ASSAY
PRECIPITATION
PROTON NUCLEAR MAGNETIC RESONANCE
SK-MEL-28 CELL LINE
SYNTHESIS
THIN LAYER CHROMATOGRAPHY
TUMOR CELL
U-87MG-LUC CELL LINE
GLIOBLASTOMA
UNDERWEIGHT
 
Описание The design of highly selective low-toxic, low-molecular weight agents for boron delivery to tumour cells is of decisive importance for the development of boron neutron capture therapy (BNCT), a modern efficient combined method for cancer treatment. In this work, we developed a simple method for the preparation of new closo- and nido-carborane-containing folic acid bis-amides containing 18–20 boron atoms per molecule. Folic acid derivatives containing nido-carborane residues were characterised by high water solubility, low cytotoxicity, and demonstrated a good ability to deliver boron to tumour cells in in vitro experiments (up to 7.0 µg B/106 cells in the case of U87 MG human glioblastoma cells). The results obtained demonstrate the high potential of folic acid–nido-carborane conjugates as boron delivery agents to tumour cells for application in BNCT. © 2022 by the authors.
Russian Science Foundation, RSF, (21-73-10073)
This research was funded by the Russian Science Foundation, grant number 21-73-10073.
 
Дата 2024-04-08T11:05:55Z
2024-04-08T11:05:55Z
2022
 
Тип Article
Journal article (info:eu-repo/semantics/article)
Published version (info:eu-repo/semantics/publishedVersion)
 
Идентификатор Gruzdev, DA, Telegina, AA, Levit, GL, Solovieva, OI, Gusel’nikova, TY, Razumov, IA, Krasnov, VP & Charushin, VN 2022, 'Carborane-Containing Folic Acid bis-Amides: Synthesis and In Vitro Evaluation of Novel Promising Agents for Boron Delivery to Tumour Cells', International Journal of Molecular Sciences, Том. 23, № 22, 13726. https://doi.org/10.3390/ijms232213726
Gruzdev, D. A., Telegina, A. A., Levit, G. L., Solovieva, O. I., Gusel’nikova, T. Y., Razumov, I. A., Krasnov, V. P., & Charushin, V. N. (2022). Carborane-Containing Folic Acid bis-Amides: Synthesis and In Vitro Evaluation of Novel Promising Agents for Boron Delivery to Tumour Cells. International Journal of Molecular Sciences, 23(22), [13726]. https://doi.org/10.3390/ijms232213726
1661-6596
Final
All Open Access; Gold Open Access; Green Open Access
https://www.mdpi.com/1422-0067/23/22/13726/pdf?version=1668498897
https://www.mdpi.com/1422-0067/23/22/13726/pdf?version=1668498897
http://elar.urfu.ru/handle/10995/131234
10.3390/ijms232213726
85142607924
000887544500001
 
Язык en
 
Связанные ресурсы info:eu-repo/grantAgreement/RSF//21-73-10073
 
Права Open access (info:eu-repo/semantics/openAccess)
cc-by
https://creativecommons.org/licenses/by/4.0/
 
Формат application/pdf
 
Издатель MDPI
 
Источник International Journal of Molecular Sciences
International Journal of Molecular Sciences