Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1)
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1)
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| Автор |
Zhukov, I. S.
Karpova, I. V. Krotova, N. A. Tissen, I. Y. Demin, K. A. Shabanov, P. D. Budygin, E. A. Kalueff, A. V. Gainetdinov, R. R. |
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| Тематика |
AGGRESSION
DOPAMINE FRONTAL CORTEX GENE KNOCKOUT GROOMING RESIDENT-INTRUDER SEROTONIN TAAR1 AGGRESSION ANIMALS GROOMING HUMANS MICE MICE, KNOCKOUT PREFRONTAL CORTEX RECEPTORS, G-PROTEIN-COUPLED SEROTONIN 3,4 DIHYDROXYPHENYLACETIC ACID 5 HYDROXYINDOLEACETIC ACID DOPAMINE G PROTEIN COUPLED RECEPTOR HOMOVANILLIC ACID SEROTONIN TRACE AMINE ASSOCIATED RECEPTOR 1 UNCLASSIFIED DRUG G PROTEIN COUPLED RECEPTOR SEROTONIN TRACE AMINE-ASSOCIATED RECEPTOR 1 AGGRESSION ANIMAL BEHAVIOR ANIMAL EXPERIMENT ARTICLE AVOIDANCE BEHAVIOR BEHAVIOR CHANGE CONTROLLED STUDY EXPLORATORY BEHAVIOR FIGHTING FREEZING FRONTAL CORTEX GENE KNOCKOUT LIMBIC CORTEX LOCOMOTION MALE MONOAMINERGIC SYSTEM MOUSE NEUROTRANSMISSION NONHUMAN OPEN FIELD TEST REARING REGULATORY MECHANISM RESIDENT-INTRUDER TEST SELF GROOMING SOCIAL DOMINANCE TISSUE LEVEL TURNOVER RATE VENTRAL STRIATUM AGGRESSION ANIMAL GROOMING HUMAN KNOCKOUT MOUSE METABOLISM PREFRONTAL CORTEX |
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| Описание |
The Trace Amine-Associated Receptor 1 (TAAR1) is one of the six functional receptors belonging to the family of monoamine-related G protein-coupled receptors (TAAR1-TAAR9) found in humans. However, the exact biological mechanisms of TAAR1 central and peripheral action remain to be fully understood. TAAR1 is widely expressed in the prefrontal cortex and several limbic regions, interplaying with the dopamine system to modulate the reward circuitry. Recent clinical trials suggest the efficacy of TAAR1 agonists as potential novel antipsychotic agents. Here, we characterize behavioral and neurochemical phenotypes of TAAR1 knockout mice, focusing on aggression and self-grooming behavior that both strongly depend on the monoaminergic signaling and cortico-striatal and cortico-limbic circuits. Overall, we report increased aggression in these knockout mice in the resident-intruder test, accompanied by reduced self-grooming behavior in the novelty-induced grooming test, and by higher cortical serotonin (5-HT) tissue levels. Further studies are necessary to explore whether TAAR1-based therapies can become potential novel treatments for a wide range of neuropsychiatric disorders associated with aggression. © 2022 by the authors.
Applied Genetics MIPT, (075-15-2021-684) Suzhou University of Science and Technology This study was supported by the project ID: 93018770 of St. Petersburg State University. K.A.D., A.V.K. and N.A.K. are supported by the project ID: 93020614 of St. Petersburg State University. A.V.K. partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). His contribution was partially supported by the Neurobiology Program of Sirius University of Science and Technology. |
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| Дата |
2024-04-08T11:05:56Z
2024-04-08T11:05:56Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Zhukov, IS, Karpova, IV, Krotova, NA, Tissen, IY, Demin, KA, Shabanov, PD, Budygin, EA, Kalueff, AV & Gainetdinov, RR 2022, 'Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1)', International Journal of Molecular Sciences, Том. 23, № 22, 14066. https://doi.org/10.3390/ijms232214066
Zhukov, I. S., Karpova, I. V., Krotova, N. A., Tissen, I. Y., Demin, K. A., Shabanov, P. D., Budygin, E. A., Kalueff, A. V., & Gainetdinov, R. R. (2022). Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1). International Journal of Molecular Sciences, 23(22), [14066]. https://doi.org/10.3390/ijms232214066 1661-6596 Final All Open Access; Gold Open Access; Green Open Access https://www.mdpi.com/1422-0067/23/22/14066/pdf?version=1668562769 https://www.mdpi.com/1422-0067/23/22/14066/pdf?version=1668562769 http://elar.urfu.ru/handle/10995/131236 10.3390/ijms232214066 85142626364 000887495400001 |
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en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
International Journal of Molecular Sciences
International Journal of Molecular Sciences |
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