Towards Zebrafish Models of CNS Channelopathies
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Towards Zebrafish Models of CNS Channelopathies
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| Автор |
Kolesnikova, T. O.
Demin, K. A. Costa, F. V. Zabegalov, K. N. de Abreu, M. S. Gerasimova, E. V. Kalueff, A. V. |
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| Тематика |
ANIMAL MODEL
BRAIN CHANNELOPATHY ION CHANNEL ZEBRAFISH ANIMALS BRAIN CHANNELOPATHIES DISEASE MODELS, ANIMAL EPILEPSY ZEBRAFISH CENTRAL NERVOUS SYSTEM AGENTS ION CHANNEL ANIMAL MODEL CENTRAL NERVOUS SYSTEM CHANNELOPATHY CENTRAL NERVOUS SYSTEM DISEASE EXPERIMENTAL DESIGN EXPERIMENTAL MODEL GENETICS NEURONAL CHANNELOPATHY NEUROPATHOLOGY NONHUMAN REVIEW ZEBRA FISH ANIMAL BRAIN CHANNELOPATHY DISEASE MODEL EPILEPSY ZEBRA FISH |
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| Описание |
Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+, Na+, Ca2+ and Cl− by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish (Danio rerio) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis. Here, we discuss current prospects and challenges of developing genetic, pharmacological and other experimental models of major CNS channelopathies based on zebrafish. © 2022 by the authors.
Applied Genetics MIPT, (075-15-2021-684) SPSU, (93020614) Sirius University, (NRB-RND-2116) Funding text 1: The research partially used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). A.V.K.’s contribution was partially supported by the SPSU funding program (Project ID 93020614). Funding text 2: The study is supported by Sirius University budgetary funds (Project ID NRB-RND-2116). |
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| Дата |
2024-04-08T11:05:56Z
2024-04-08T11:05:56Z 2022 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Kolesnikova, TO, Demin, KA, Costa, FV, Zabegalov, KN, de Abreu, MS, Gerasimova, EV & Kalueff, AV 2022, 'Towards Zebrafish Models of CNS Channelopathies', International Journal of Molecular Sciences, Том. 23, № 22, 13979. https://doi.org/10.3390/ijms232213979
Kolesnikova, T. O., Demin, K. A., Costa, F. V., Zabegalov, K. N., de Abreu, M. S., Gerasimova, E. V., & Kalueff, A. V. (2022). Towards Zebrafish Models of CNS Channelopathies. International Journal of Molecular Sciences, 23(22), [13979]. https://doi.org/10.3390/ijms232213979 1661-6596 Final All Open Access; Gold Open Access; Green Open Access https://www.mdpi.com/1422-0067/23/22/13979/pdf?version=1668249011 https://www.mdpi.com/1422-0067/23/22/13979/pdf?version=1668249011 http://elar.urfu.ru/handle/10995/131237 10.3390/ijms232213979 85142788186 000887378400001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
International Journal of Molecular Sciences
International Journal of Molecular Sciences |
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