Acute behavioral and Neurochemical Effects of Novel N-Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Acute behavioral and Neurochemical Effects of Novel N-Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish
|
|
| Автор |
Demin, K. A.
Kupriyanova, O. V. Shevyrin, V. A. Derzhavina, K. A. Krotova, N. A. Ilyin, N. P. Kolesnikova, T. O. Galstyan, D. S. Kositsyn, Y. M. Khaybaev, A. -A. S. Seredinskaya, M. V. Dubrovskii, Y. Sadykova, R. G. Nerush, M. O. Mor, M. S. Petersen, E. V. Strekalova, T. Efimova, E. V. Kuvarzin, S. R. Yenkoyan, K. B. Bozhko, D. V. Myrov, V. O. Kolchanova, S. M. Polovian, A. I. Galumov, G. K. Kalueff, A. V. |
|
| Тематика |
AI-PHENOTYPING
BEHAVIOR IN SILICO DRUG ACTIVITY NOVEL COMPOUNDS PSYCHOPHARMACOLOGY ZEBRAFISH ANIMALS ARTIFICIAL INTELLIGENCE BEHAVIOR, ANIMAL HALLUCINOGENS PHENETHYLAMINES ZEBRAFISH 3,4 DIHYDROXYPHENYLACETIC ACID 5 HYDROXYINDOLEACETIC ACID BENZYL DERIVATIVE DOPAMINE HOMOVANILLIC ACID KETAMINE LYSERGIDE MIDOMAFETAMINE NORADRENALIN PHENETHYLAMINE DERIVATIVE PSYCHEDELIC AGENT SEROTONIN TETRAHYDROCANNABINOL PHENETHYLAMINE PHENETHYLAMINE DERIVATIVE PSYCHEDELIC AGENT ADULT ANIMAL EXPERIMENT ANIMAL TISSUE ANXIETY ARTICLE ARTIFICIAL INTELLIGENCE BEHAVIOR ASSESSMENT CONTROLLED STUDY DOPAMINE BRAIN LEVEL FEMALE IN VIVO STUDY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY LOCOMOTION MALE MOLECULAR MODEL NEUROCHEMISTRY NONHUMAN PHENOTYPE QUALITATIVE ANALYSIS SCREENING SEROTONIN BRAIN LEVEL SUBSTITUTION REACTION ZEBRA FISH ANIMAL ANIMAL BEHAVIOR CHEMISTRY |
|
| Описание |
Hallucinogenic drugs potently affect brain and behavior and have also recently emerged as potentially promising agents in pharmacotherapy. Complementing laboratory rodents, the zebrafish (Danio rerio) is a powerful animal model organism for screening neuroactive drugs, including hallucinogens. Here, we test a battery of ten novel N-benzyl-2-phenylethylamine (NBPEA) derivatives with the 2,4- and 3,4-dimethoxy substitutions in the phenethylamine moiety and the -OCH3, -OCF3, -F, -Cl, and -Br substitutions in the ortho position of the phenyl ring of the N-benzyl moiety, assessing their acute behavioral and neurochemical effects in the adult zebrafish. Overall, substitutions in the Overall, substitutions in the N-benzyl moiety modulate locomotion, and substitutions in the phenethylamine moiety alter zebrafish anxiety-like behavior, also affecting the brain serotonin and/or dopamine turnover. The 24H-NBOMe(F) and 34H-NBOMe(F) treatment also reduced zebrafish despair-like behavior. Computational analyses of zebrafish behavioral data by artificial intelligence identified several distinct clusters for these agents, including anxiogenic/hypolocomotor (24H-NBF, 24H-NBOMe, and 34H-NBF), behaviorally inert (34H-NBBr, 34H-NBCl, and 34H-NBOMe), anxiogenic/hallucinogenic-like (24H-NBBr, 24H-NBCl, and 24H-NBOMe(F)), and anxiolytic/hallucinogenic-like (34H-NBOMe(F)) drugs. Our computational analyses also revealed phenotypic similarity of the behavioral activity of some NBPEAs to that of selected conventional serotonergic and antiglutamatergic hallucinogens. In silico functional molecular activity modeling further supported the overlap of the drug targets for NBPEAs tested here and the conventional serotonergic and antiglutamatergic hallucinogens. Overall, these findings suggest potent neuroactive properties of several novel synthetic NBPEAs, detected in a sensitive in vivo vertebrate model system, the zebrafish, raising the possibility of their potential clinical use and abuse. © 2022 American Chemical Society. All rights reserved.
Saint Petersburg State University, SPbU, (93020614) Suzhou University of Science and Technology, (NRB-RND-2116) Kazan Federal University, (0671-2020-0058, PRIORITY-2030) Ministry of Health of the Russian Federation, (121040200141-4) The laboratory is supported by the Ministry of Health of the Russian Federation funds 121040200141-4. AVK, NAK, and NPI were supported by St. Petersburg State University budgetary funds (project ID 93020614). TKO was supported by the Sirius University of Science and Technology (project ID NRB-RND-2116). A.V.K. is the chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) and president of the International Stress and Behavior Society (ISBS, www.stress-and-behavior.com ) that coordinated this collaborative multilaboratory project. The consortium provided a collaborative idea exchange platform for this study. It is not considered as an affiliation and did not fund the study. The study used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (Support grant 075-15-2021-684). O.V.K. is supported by the subsidy allocated to the Kazan Federal University for the state research assignment (project #0671-2020-0058) the research was a part of the Kazan Federal University Strategic Academic Leadership Program (PRIORITY-2030). The funders had no role in the design, analyses, and interpretation of the submitted study or the decision to publish. |
|
| Дата |
2024-04-08T11:06:07Z
2024-04-08T11:06:07Z 2022 |
|
| Тип |
Article
Journal article (info:eu-repo/semantics/article) info:eu-repo/semantics/submittedVersion |
|
| Идентификатор |
Demin, KA, Kupriyanova, OV, Shevyrin, VA, Derzhavina, KA, Krotova, NA, Ilyin, NP, Kolesnikova, TO, Galstyan, DS, Kositsyn, YM, Khaybaev, AAS, Seredinskaya, MV, Dubrovskii, Y, Sadykova, RG, Nerush, MO, Mor, MS, Petersen, EV, Strekalova, T, Efimova, EV, Kuvarzin, SR, Yenkoyan, KB, Bozhko, DV, Myrov, VO, Kolchanova, SM, Polovian, AI, Galumov, GK & Kalueff, AV 2022, 'Acute behavioral and Neurochemical Effects of Novel N-Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish', ACS Chemical Neuroscience, Том. 13, № 13, стр. 1902-1922. https://doi.org/10.1021/acschemneuro.2c00123
Demin, K. A., Kupriyanova, O. V., Shevyrin, V. A., Derzhavina, K. A., Krotova, N. A., Ilyin, N. P., Kolesnikova, T. O., Galstyan, D. S., Kositsyn, Y. M., Khaybaev, A. A. S., Seredinskaya, M. V., Dubrovskii, Y., Sadykova, R. G., Nerush, M. O., Mor, M. S., Petersen, E. V., Strekalova, T., Efimova, E. V., Kuvarzin, S. R., ... Kalueff, A. V. (2022). Acute behavioral and Neurochemical Effects of Novel N-Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish. ACS Chemical Neuroscience, 13(13), 1902-1922. https://doi.org/10.1021/acschemneuro.2c00123 1948-7193 Final All Open Access; Green Open Access https://www.biorxiv.org/content/biorxiv/early/2022/01/21/2022.01.19.476767.full.pdf https://www.biorxiv.org/content/biorxiv/early/2022/01/21/2022.01.19.476767.full.pdf http://elar.urfu.ru/handle/10995/131279 10.1021/acschemneuro.2c00123 85133475586 |
|
| Язык |
en
|
|
| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
| Формат |
application/pdf
|
|
| Издатель |
American Chemical Society
|
|
| Источник |
ACS Chemical Neuroscience
ACS Chemical Neuroscience |
|