Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
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| Автор |
Kovalev, I. S.
Zyryanov, G. V. Santra, S. Majee, A. Varaksin, M. V. Charushin, V. N. |
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| Тематика |
ANTIFOLATES
APPLICATIONS DRUGS FOLIC ACIDS SYNTHESIS |
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| Описание |
Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotrexate (MTX), Raltitrexed (Tomudex, ZD1694), Pralatrexate, Pemetrexed, TNP-351, and Lometrexol. In addition, the applications or uses of these folic acid antimetabolites are also discussed. © 2022 by the authors.
Ministry of Science, ICT and Future Planning, MSIP, (075-15-2022-1118) Russian Science Foundation, RSF, (20-43-01004) The analysis of synthetic approaches to antifolates was supported by the Russian Science Foundation (Project # 20-43-01004). The analysis of biological activity of antifolates was supported by the Ministry of Science and the Higher Education of RF (Ref. # 075-15-2022-1118, dated 29 June 2022). |
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| Дата |
2024-04-08T11:06:35Z
2024-04-08T11:06:35Z 2022 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Kovalev, IS, Zyryanov, GV, Santra, S, Majee, A, Varaksin, MV & Charushin, VN 2022, 'Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities', Molecules, Том. 27, № 19, 6229. https://doi.org/10.3390/molecules27196229
Kovalev, I. S., Zyryanov, G. V., Santra, S., Majee, A., Varaksin, M. V., & Charushin, V. N. (2022). Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities. Molecules, 27(19), [6229]. https://doi.org/10.3390/molecules27196229 1420-3049 Final All Open Access; Gold Open Access; Green Open Access https://www.mdpi.com/1420-3049/27/19/6229/pdf?version=1663838338 https://www.mdpi.com/1420-3049/27/19/6229/pdf?version=1663838338 http://elar.urfu.ru/handle/10995/131317 10.3390/molecules27196229 85139962002 000866947400001 |
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| Язык |
en
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| Связанные ресурсы |
info:eu-repo/grantAgreement/RSF//20-43-01004
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
MDPI
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| Источник |
Molecules
Molecules |
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