Evaluation of Anti-Infectious Activity of Bioconjugates Based on Quantum Dots CdTe / Cd MPA 710 and Levofloxacin against Staphylococcal Corneal Infection. Experimental Research
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Evaluation of Anti-Infectious Activity of Bioconjugates Based on Quantum Dots CdTe / Cd MPA 710 and Levofloxacin against Staphylococcal Corneal Infection. Experimental Research
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| Автор |
Ponomarev, V. O.
Kazaykin, V. N. Tkachenko, K. A. Vokhmintsev, A. S. Vainshtein, I. A. Rozanova, S. M. Kirf, M. V. Marysheva, S. V. |
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| Тематика |
ANTIBIOTICS
BACTERIAL KERATITIS BIOCONJUGATES CORNEA EFFICACY LEVOFLOXACIN QUANTUM DOTS RESISTANCE CD MPA 710 QUANTUM DOT LEVOFLOXACIN CONJUGATE CDTE QUANTUM DOT LEVOFLOXACIN CONJUGATE LEVOFLOXACIN QUANTUM DOT UNCLASSIFIED DRUG ANIMAL EXPERIMENT ANIMAL MODEL ARTICLE BACTERIAL KERATITIS BACTERIAL STRAIN CONJUGATE CONTROLLED STUDY CORNEA EXPERIMENTAL ANIMAL MALE NEW ZEALAND RABBIT NONHUMAN STAPHYLOCOCCUS INFECTION |
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| Описание |
Infectious keratitis is one of the leading causes of persistent decline in visual function and monocular blindness in both developed and developing countries. The combination of factors in the prevalence of eye infectious and inflammatory diseases, antibiotic resistance, and internal mutations of the pathogens themselves exacerbate the need to search for highly effective alternatives in the fight against eye infectious diseases. Of particular interest are the prospects for the use of fluorescent semiconductor nanocrystals, called quantum dots, in the treatment of resistant infectious inflammatory diseases. The objective of the study was to assess the anti- infectious activity of bioconjugates based on CdTe / Cd MPA 710 quantum dots and levofloxacin against staphylococcal corneal infection using the example induced infectious keratitis in laboratory animals. As the object of the study, 6 male (6 eyes) New Zealand rabbits were studied, which underwent induction of bacterial keratitis by introducing a hospital strain of S. Aureus into the structure of the cornea. The following were used as antimicrobial agents: a solution of levofloxacin 5 ml for epibulbar use and a bioconjugate based on CT CdTe / Cd MPA 710 and levofloxacin. © 2022 Ophthalmology Publishing Group. All rights reserved.
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| Дата |
2024-04-08T11:06:56Z
2024-04-08T11:06:56Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Пономарев, ВО, Казайкин, ВН, Ткаченко, КА, Вохминцев, АС, Вайнштейн, ИА, Розанова, СМ, Кырф, МВ & Марышева, СВ 2022, 'ОЦЕНКА АНТИИНФЕКЦИОННОЙ АКТИВНОСТИ БИОКОНЪЮГАТОВ НА ОСНОВЕ КВАНТОВЫХ ТОЧЕК CDTE/CD MPA 710 И ЛЕВОФЛОКСАЦИНА В ОТНОШЕНИИ СТАФИЛОКОККОВОЙ ИНФЕКЦИИ РОГОВИЦЫ. ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ', Офтальмология, Том. 19, № 4, стр. 808-814. https://doi.org/10.18008/1816-5095-2022-4-808-814
Пономарев, В. О., Казайкин, В. Н., Ткаченко, К. А., Вохминцев, А. С., Вайнштейн, И. А., Розанова, С. М., Кырф, М. В., & Марышева, С. В. (2022). ОЦЕНКА АНТИИНФЕКЦИОННОЙ АКТИВНОСТИ БИОКОНЪЮГАТОВ НА ОСНОВЕ КВАНТОВЫХ ТОЧЕК CDTE/CD MPA 710 И ЛЕВОФЛОКСАЦИНА В ОТНОШЕНИИ СТАФИЛОКОККОВОЙ ИНФЕКЦИИ РОГОВИЦЫ. ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ. Офтальмология, 19(4), 808-814. https://doi.org/10.18008/1816-5095-2022-4-808-814 1816-5095 Final All Open Access; Gold Open Access https://www.ophthalmojournal.com/opht/article/download/1990/1048 https://www.ophthalmojournal.com/opht/article/download/1990/1048 http://elar.urfu.ru/handle/10995/131371 50035085 10.18008/1816-5095-2022-4-808-814 85147701726 |
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| Язык |
ru
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Ophthalmology Publishing Group
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| Источник |
Ophthalmology in Russia
Oftalmologiya |
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