Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue
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| Автор |
Elmas, O.
Sahin, H. H. K. Keskin, E. Guven, B. Uslu, Erdemir, R. Almisned, G. Zakaly, H. M. H. Ene, A. Tekin, H. O. |
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| Тематика |
ANNONA MURICATA
APOPTOSIS IRRADIATION OXIDATIVE STRESS RADIOPROTECTIVE |
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| Описание |
We report the radioprotective attitude of Annona muricata (AM) leaf extract as antioxidant material to prevent cellular damage in the ileum tissue. The protective effects of an ethyl acetate extract of AM leaves are comprehensively investigated against radiation-induced ileal damage in numerous rats. Thirty-two adult female rats were separated into 4 groups (3 intervention groups and 1 control) as follows: controls received 0.01 mL/kg distilled water, the AM group received 300 mg/kg AM leaf extract, the ionizing radiation (IR) group received a single dose of whole body radiation (8.3 Gy) after 0.01 mL/kg saline treatment, and the AM + IR group received 300 mg/kg AM leaf extract treatment and were subjected to whole body radiation (8.3 Gy) 1 h after the last gavage. All treatments are administered by oral gavage once a day for 9 days. At the end of the experiment, biochemical total oxidant status (TOS, interleukin-6, and caspase) and histological examinations are performed on blood samples as well as ileum tissue. TOS levels are found to be significantly high in rats, which received irradiation, and those in the AM group when compared to controls. These findings suggest that AM has radioprotective effects on ileum tissue, likely because of its antioxidative properties. The findings of this research may contribute to the minimizing of major side effects induced by excessive radiation exposure in patients undergoing radiotherapy and may serve as a significant impetus for further assessments. However, future studies are highly recommended to confirm safety and to determine extraction technique and dosage before human use can be considered. © 2022 Ozlem Elmas et al.
Dunarea de Jos” University of Galati, (RF 3621/2021) Universitatea 'Dunărea de Jos' Galați, UDJG Funding text 1: Funding information: The work of Antoaneta ENE and the APC were supported by Dunarea de Jos University of Galati, Romania through the grant no. RF 3621/2021. Funding text 2: Author contributions: O.E., H.H.K.S., and H.O.T.: – conceptualization and methodology E.K., B.G., G.A., and R.U.E.: validation G.A. and H.M.H.Z.: formal analysis O.E., H.H.K.S., E.K., B.G., and H.O.T.: writing and review O.E., H.H.K.S., E.K., B.G., and A.E.: investigation A.E.: funding acquisition through APC by “Dunarea de Jos” University of Galati, Romania through the grant no. RF 3621/2021. |
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| Дата |
2024-04-08T11:06:57Z
2024-04-08T11:06:57Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Elmas, O, Sahin, HHK, Keskin, E, Guven, B, Uslu Erdemir, R, Almisned, G, Zakaly, HMH, Ene, A & Tekin, HO 2022, 'Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue', Open chemistry, Том. 20, № 1, стр. 929-938. https://doi.org/10.1515/chem-2022-0205
Elmas, O., Sahin, H. H. K., Keskin, E., Guven, B., Uslu Erdemir, R., Almisned, G., Zakaly, H. M. H., Ene, A., & Tekin, H. O. (2022). Clinical comprehensive and experimental assessment of the radioprotective effect of Annona muricata leaf extract to prevent cellular damage in the ileum tissue. Open chemistry, 20(1), 929-938. https://doi.org/10.1515/chem-2022-0205 2391-5420 Final All Open Access; Gold Open Access https://www.degruyter.com/document/doi/10.1515/chem-2022-0205/pdf https://www.degruyter.com/document/doi/10.1515/chem-2022-0205/pdf http://elar.urfu.ru/handle/10995/131373 10.1515/chem-2022-0205 85139209329 000858415500001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
De Gruyter Open Ltd
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| Источник |
Open Chemistry
Open Chemistry |
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