A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies
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| Автор |
Elmas, O.
Sahin, H. H. K. Guven, B. Abuzaid, M. M. Elshami, W. Almisned, G. Zakaly, H. M. H. Ene, A. Tekin, H. O. |
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| Тематика |
ANNONA MURICATA
APOPTOSIS IRRADIATION OXIDATIVE STRESS RADIOPROTECTIVE |
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| Описание |
Objectives: This study investigates the effect of Annona muricata (AM) leaf extract against irradiation-induced damage by the evaluation of hepatic tissue and the levels of oxidative and inflammatory stress in the circulation. Methods: An experimental study with 37 female Wistar albino rats randomized into four groups (controls and three intervention groups) was performed. The first interventional group (group 2) received 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days, group 3 received a single dose of whole-body radiation (8.3 Gy) after a 9-day oral gavage treatment with saline, and the last group received the same irradiation of 8.3 Gy after being treated with 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days. Results: Radiation was found to elevate reactive oxygen species parameters, and AM administration before irradiation was found to decrease total oxidant status (TOS), increase caspase 9, and improve hepatic damage when compared with the group that received only irradiation. Conclusion: The damage caused by irradiation may be ameliorated by the use of the AM extract, which appears to be effective in preventing oxidative stress and inflammatory activity. © 2022 Ozlem Elmas et al.
Dunarea de Jos” University of Galati Universitatea 'Dunărea de Jos' Galați, UDJG, (RF 3621/2021) Funding text 1: Author contributions: O.E., H.H.K.S., H.O.T.: conceptualization and methodology M.A., W.E., G.A.: validation G.A. and H.M.H.Z.: formal analysis O.E., H.H.K.S., B.G., H.O.T.: writing and review O.E., H.H.K.S., B.G., A.E., M.A., W.E.: investigation A.E.: funding acquisition through APC by “Dunarea de Jos” University of Galati, Romania through the grant no. RF 3621/2021. Funding text 2: Funding information: The work of Antoaneta ENE and the APC were supported by Dunarea de Jos University of Galati, Romania through the grant no. RF 3621/2021. |
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| Дата |
2024-04-08T11:06:57Z
2024-04-08T11:06:57Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Elmas, O, Sahin, HHK, Guven, B, Abuzaid, MM, Elshami, W, Almisned, G, Zakaly, HMH, Ene, A & Tekin, HO 2022, 'A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies', Open chemistry, Том. 20, № 1, стр. 920-928. https://doi.org/10.1515/chem-2022-0206
Elmas, O., Sahin, H. H. K., Guven, B., Abuzaid, M. M., Elshami, W., Almisned, G., Zakaly, H. M. H., Ene, A., & Tekin, H. O. (2022). A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies. Open chemistry, 20(1), 920-928. https://doi.org/10.1515/chem-2022-0206 2391-5420 Final All Open Access; Gold Open Access https://www.degruyter.com/document/doi/10.1515/chem-2022-0206/pdf https://www.degruyter.com/document/doi/10.1515/chem-2022-0206/pdf http://elar.urfu.ru/handle/10995/131374 10.1515/chem-2022-0206 85139254835 000858430000001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
De Gruyter Open Ltd
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| Источник |
Open Chemistry
Open Chemistry |
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