Control of the chirality of spiral waves and recreation of spatial excitation patterns through optogenetics
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Control of the chirality of spiral waves and recreation of spatial excitation patterns through optogenetics
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| Автор |
Li, T. -C.
Zhong, W. Ai, B. -Q. Panfilov, A. V. Dierckx, H. |
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| Тематика |
ATOMIC PHYSICS
EXCITABLE SYSTEMS EXCITATION PATTERN NUMERICAL EVIDENCE OPTOGENETICS PHASE DIFFERENCE SHAPED ILLUMINATION SPATIAL PATTERNS SPIRAL WAVES TURBULENT SYSTEMS ARTICLE CHIRALITY EXCITATION OPTOGENETICS RECREATION CHIRALITY |
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| Описание |
Spiral waves lead to dangerous arrhythmias in the cardiac system. In 2015 Burton et al. demonstrated the reversal of the spiral wave chirality through the rotating spiral-shaped illumination on the optogenetically modified cardiac monolayers. We show that this process entails the recreation of a spiral wave. We show how this methodology can be used to control and create the desired spatial excitation pattern. We found that the control is sensitive to the area of illuminated region but independent of the phase difference of the existing spiral wave and the applied spiral-shaped light. We also discovered that our methodology can temporarily resynchronize a turbulent system. The results offer numerical evidence for the control of spatial pattern in biological excitable systems with optogenetics. © 2022 American Physical Society.
National Natural Science Foundation of China, NSFC, (12005066) Ministry of Education and Science of the Russian Federation, Minobrnauka, (075-15-2020-926) This work was supported by the National Natural Science Foundation of China under Grant No. 12005066. Research at Sechenov University was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of world-class research centers, “Digital Biodesign and Personalized Healthcare,” No. 075-15-2020-926. We thank H. Zhang for valuable discussions. |
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| Дата |
2024-04-08T11:07:03Z
2024-04-08T11:07:03Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Li, TC, Zhong, W, Ai, BQ, Panfilov, AV & Dierckx, H 2022, 'Control of the chirality of spiral waves and recreation of spatial excitation patterns through optogenetics', Physical Review E, Том. 105, № 1, 014214. https://doi.org/10.1103/PhysRevE.105.014214
Li, T. C., Zhong, W., Ai, B. Q., Panfilov, A. V., & Dierckx, H. (2022). Control of the chirality of spiral waves and recreation of spatial excitation patterns through optogenetics. Physical Review E, 105(1), [014214]. https://doi.org/10.1103/PhysRevE.105.014214 2470-0045 Final All Open Access; Green Open Access https://biblio.ugent.be/publication/01H30B6AYCY92WW4ZVFTMQYKMH/file/01H322P0EXPFD5FE52EVXP8GV5.pdf https://biblio.ugent.be/publication/01H30B6AYCY92WW4ZVFTMQYKMH/file/01H322P0EXPFD5FE52EVXP8GV5.pdf http://elar.urfu.ru/handle/10995/131395 10.1103/PhysRevE.105.014214 85124472994 000753927000001 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
American Physical Society
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| Источник |
Physical Review E
Physical Review E |
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