Control of spiral waves in optogenetically modified cardiac tissue by periodic optical stimulation
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Control of spiral waves in optogenetically modified cardiac tissue by periodic optical stimulation
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| Автор |
Li, Q. -H.
Xia, Y. -X. Xu, S. -X. Song, Z. Pan, J. -T. Panfilov, A. V. Zhang, H. |
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| Тематика |
HEART
TISSUE CARDIAC CELL CARDIAC TISSUES DETAILED MODELS EXCITABLE MEDIA IONIC CURRENT NOVEL METHODOLOGY OPTICAL STIMULATION OPTICAL- OPTOGENETICS SPIRAL WAVES ARTICLE HEART TISSUE ION CURRENT QUANTITATIVE ANALYSIS ROTATION THEORETICAL STUDY VELOCITY DEPOLARIZATION |
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| Описание |
Resonant drift of nonlinear spiral waves occurs in various types of excitable media under periodic stimulation. Recently a novel methodology of optogenetics has emerged, which allows to affect excitability of cardiac cells and tissues by optical stimuli. In this paper we study if resonant drift of spiral waves in the heart can be induced by a homogeneous weak periodic optical stimulation of cardiac tissue. We use a two-variable and a detailed model of cardiac tissue and add description of depolarizing and hyperpolarizing optogenetic ionic currents. We show that weak periodic optical stimulation at a frequency equal to the natural rotation frequency of the spiral wave induces resonant drift for both depolarizing and hyperpolarizing optogenetic currents. We quantify these effects and study how the speed of the drift and its direction depend on the initial conditions. We also derive analytical formulas based on the response function theory which correctly predict the drift velocity and its trajectory. We conclude that optogenetic methodology can be used for control of spiral waves in cardiac tissue and discuss its possible applications. © 2022 American Physical Society.
National Natural Science Foundation of China, NSFC, (12075203) Ministry of Education and Science of the Russian Federation, Minobrnauka, (075-15-2020-926) We are thankful to I. V. Biktasheva and V. N. Biktashev for valuable comments. This work was supported by the National Natural Science Foundation of China under Grant No. 12075203, and Research at Sechenov University was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers “Digital biodesign and personalized healthcare” Grant No. 075-15-2020-926. |
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| Дата |
2024-04-08T11:07:04Z
2024-04-08T11:07:04Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Li, QH, Xia, YX, Xu, SX, Song, Z, Pan, JT, Panfilov, AV & Zhang, H 2022, 'Control of spiral waves in optogenetically modified cardiac tissue by periodic optical stimulation', Physical Review E, Том. 105, № 4, 044210. https://doi.org/10.1103/PhysRevE.105.044210
Li, Q. H., Xia, Y. X., Xu, S. X., Song, Z., Pan, J. T., Panfilov, A. V., & Zhang, H. (2022). Control of spiral waves in optogenetically modified cardiac tissue by periodic optical stimulation. Physical Review E, 105(4), [044210]. https://doi.org/10.1103/PhysRevE.105.044210 2470-0045 Final All Open Access; Green Open Access https://biblio.ugent.be/publication/01H3235G2FE9V9GZJH5WPT2JKJ/file/01H323ASSG5HDBZST5Y2SXCGV9.pdf https://biblio.ugent.be/publication/01H3235G2FE9V9GZJH5WPT2JKJ/file/01H323ASSG5HDBZST5Y2SXCGV9.pdf http://elar.urfu.ru/handle/10995/131396 10.1103/PhysRevE.105.044210 85129769324 000798342700009 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
American Physical Society
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| Источник |
Physical Review E
Physical Review E |
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