Spiral wave drift under optical feedback in cardiac tissue
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Spiral wave drift under optical feedback in cardiac tissue
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| Автор |
Xia, Y. -X.
Zhi, X. -P. Li, T. -C. Pan, J. -T. Panfilov, A. V. Zhang, H. |
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| Тематика |
COMPUTER SIMULATION
FEEDBACK HEART ELECTRIC FIELDS FEEDBACK CONTROL HEART IONS LIGHT LIGHT SENSITIVE MATERIALS LIGHT SOURCES MATHEMATICAL OPERATORS PHOTOSENSITIVITY CARDIAC TISSUES EXCITABLE MEDIA EXCITATION PATTERN EXTERNAL ELECTRIC FIELD FORCINGS GRADIENT TERMS ION CHANNEL SPIRAL WAVE DYNAMICS SPIRAL WAVES WAVE DRIFT COMPUTER SIMULATION FEEDBACK SYSTEM HEART TISSUE |
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| Описание |
Spiral waves occur in various types of excitable media and their dynamics determine the spatial excitation patterns. An important type of spiral wave dynamics is drift, as it can control the position of a spiral wave or eliminate a spiral wave by forcing it to the boundary. In theoretical and experimental studies of the Belousov-Zhabotinsky reaction, it was shown that the most direct way to induce the controlled drift of spiral waves is by application of an external electric field. Mathematically such drift occurs due to the onset of additional gradient terms in the Laplacian operator describing excitable media. However, this approach does not work for cardiac excitable tissue, where an external electric field does not result in gradient terms. In this paper, we propose a method of how to induce a directed linear drift of spiral waves in cardiac tissue, which can be realized as an optical feedback control in tissue where photosensitive ion channels are expressed. We illustrate our method by using the FitzHugh-Nagumo model for cardiac tissue and the generic model of photosensitive ion channels. We show that our method works for continuous and discrete light sources and can effectively move spiral waves in cardiac tissue, or eliminate them by collisions with the boundary or with another spiral wave. We finally implement our method by using a biophysically motivated photosensitive ion channel model included to the Luo-Rudy model for cardiac cells and show that the proposed feedback control also induces directed linear drift of spiral waves in a wide range of light intensities. © 2022 American Physical Society.
National Natural Science Foundation of China, NSFC, (12005066, 12075203) Ministry of Education and Science of the Russian Federation, Minobrnauka, (075-15-2020-926) We thank D. Pijnappels, Q. H. Li, and Y. J. He for helpful discussions. This work was supported by the National Natural Science Foundation of China under Grants No. 12075203 and No. 12005066, and research at Sechenov University was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers “Digital Biodesign and Personalized Healthcare” 075-15-2020-926. |
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| Дата |
2024-04-08T11:07:04Z
2024-04-08T11:07:04Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Xia, YX, Zhi, XP, Li, TC, Pan, JT, Panfilov, AV & Zhang, H 2022, 'Spiral wave drift under optical feedback in cardiac tissue', Physical Review E, Том. 106, № 2, 024405. https://doi.org/10.1103/PhysRevE.106.024405
Xia, Y. X., Zhi, X. P., Li, T. C., Pan, J. T., Panfilov, A. V., & Zhang, H. (2022). Spiral wave drift under optical feedback in cardiac tissue. Physical Review E, 106(2), [024405]. https://doi.org/10.1103/PhysRevE.106.024405 2470-0045 Final All Open Access; Green Open Access https://biblio.ugent.be/publication/01H30AVGKPM89JQ87Z9NQSG10E/file/01H322FR7H3J308MY7ZHRKN6BR.pdf https://biblio.ugent.be/publication/01H30AVGKPM89JQ87Z9NQSG10E/file/01H322FR7H3J308MY7ZHRKN6BR.pdf http://elar.urfu.ru/handle/10995/131397 10.1103/PhysRevE.106.024405 85136195314 000869899600003 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
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| Формат |
application/pdf
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| Издатель |
American Physical Society
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| Источник |
Physical Review E
Physical Review E |
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