Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?
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| Автор |
Svirin, E.
de Munter, J. Umriukhin, A. Sheveleva, E. Kalueff, A. V. Svistunov, A. Morozov, S. Walitza, S. Strekalova, T. |
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| Тематика |
INSULIN RECEPTOR SIGNALLING
MAJOR BRAIN GANGLIOSIDES MICE MYELINATION NEURODEVELOPMENTAL DISORDERS NEUROINFLAMMATION ANIMALS CYTOKINES G(M1) GANGLIOSIDE GANGLIOSIDES GENOME-WIDE ASSOCIATION STUDY INSULIN LACTOSYLCERAMIDES MAMMALS MICE RECEPTOR, INSULIN CYTOKINE GANGLIOSIDE GANGLIOSIDE GD 1A GANGLIOSIDE GD 1B INSULIN RECEPTOR INTERLEUKIN 1BETA INTERLEUKIN 6 LACTOSYLCERAMIDE TUMOR NECROSIS FACTOR CYTOKINE GANGLIOSIDE GANGLIOSIDE GM1 INSULIN ANTIINFLAMMATORY ACTIVITY APOPTOSIS ASTROCYTE ATTENTION DEFICIT HYPERACTIVITY DISORDER AUTISM CELL ADHESION CELL MEMBRANE CELL PROLIFERATION CENTRAL NERVOUS SYSTEM DISEASE FUNCTIONAL CONNECTIVITY GENE EXPRESSION GENETIC ASSOCIATION GENOME-WIDE ASSOCIATION STUDY GENOTYPE GRAY MATTER INSULIN SENSITIVITY INSULIN SIGNALING LIPID METABOLISM MACROPHAGE MAMMAL CELL MENTAL DISEASE MICROGLIA MYELIN SHEATH MYELINATION NERVE CELL PLASTICITY NERVE FUNCTION NERVOUS SYSTEM DEVELOPMENT NERVOUS SYSTEM INFLAMMATION NEURITE OUTGROWTH NEUROLOGIC DISEASE NONHUMAN OXIDATIVE STRESS PROTEIN EXPRESSION PROTEIN FUNCTION REVIEW RISK FACTOR SIALYLATION SIGNAL TRANSDUCTION SYNAPTOSOME SYNTHESIS UPREGULATION ANIMAL MAMMAL METABOLISM MOUSE |
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| Описание |
Gangliosides are molecules widely present in the plasma membranes of mammalian cells, participating in a variety of processes, including protein organization, transmembrane signalling and cell adhesion. Gangliosides are abundant in the grey matter of the brain, where they are critically involved in postnatal neural development and function. The common precursor of the majority of brain gangliosides, GM3, is formed by the sialylation of lactosylceramide, and four derivatives of its a- and b-series, GM1, GD1a, GD1b and GT1b, constitute 95% of all the brain gangliosides. Impairments in ganglioside metabolism due to genetic abnormalities of GM-synthases are associated with severe neurological disorders. Apart from that, the latest genome-wide association and translational studies suggest a role of genes involved in brain ganglioside synthesis in less pervasive psychiatric disorders. Remarkably, the most recent animal studies showed that abnormal ganglioside functions result in dysregulated neuroinflammation, aberrant myelination and altered insulin receptor signalling. At the same time, these molecular features are well established as accompanying developmental psychiatric disorders such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). This led us to hypothesize a role of deficient ganglioside function in developmental neuropsychiatric disorders and warrants further gene association clinical studies addressing this question. Here, we critically review the literature to discuss this hypothesis and focus on the recent studies on ST3GAL5-deficient mice. In addition, we elaborate on the therapeutic potential of various anti-inflammatory remedies for treatment of developmental neuropsychiatric conditions related to aberrant ganglioside functions. © 2022 by the authors.
Eat2beNice EU framework, (FGFU-2022-0012, FGFU-2022-0013) Horizon 2020 Framework Programme, H2020, (101007642, 728018) European Commission, EC This study was supported by Eat2beNice EU framework (2018–2023, to T.S.), by PhytoAPP EU framework (2021–2025, to E.S., S.L. and T.S.), Swiss-RF program-2020 (to T.S., S.W. and E.S.), FGFU-2022-0012 and FGFU-2022-0013 (to E.S., S.M., E.S. (Elisaveta Sheveleva), T.S.), and Priority Program-2030 (to E.S., A.U., E.S. (Elisaveta Sheveleva), A.S., T.S.). The Eat2beNICE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 728018 and the PhytoAPP project has received funding from the European Union’s HORIZON 2020 research and innovation programme under the Marie Sklodowvska-Curie grant agreement 101007642. This publication reflects only the author’s views and the European Commission is not liable for any use that may be made of the information contained therein. |
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| Дата |
2024-04-08T11:07:09Z
2024-04-08T11:07:09Z 2022 |
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| Тип |
Review
Review (info:eu-repo/semantics/review) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Svirin, E, de Munter, J, Umriukhin, A, Sheveleva, E, Kalueff, AV, Svistunov, A, Morozov, S, Walitza, S & Strekalova, T 2022, 'Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy?', Biomolecules, Том. 12, № 10, 1434. https://doi.org/10.3390/biom12101434
Svirin, E., de Munter, J., Umriukhin, A., Sheveleva, E., Kalueff, A. V., Svistunov, A., Morozov, S., Walitza, S., & Strekalova, T. (2022). Aberrant Ganglioside Functions to Underpin Dysregulated Myelination, Insulin Signalling, and Cytokine Expression: Is There a Link and a Room for Therapy? Biomolecules, 12(10), [1434]. https://doi.org/10.3390/biom12101434 2218-273X Final All Open Access; Gold Open Access; Green Open Access https://www.mdpi.com/2218-273X/12/10/1434/pdf?version=1665146350 https://www.mdpi.com/2218-273X/12/10/1434/pdf?version=1665146350 http://elar.urfu.ru/handle/10995/131413 10.3390/biom12101434 85140486962 000872298300001 |
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en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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application/pdf
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MDPI
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| Источник |
Biomolecules
Biomolecules |
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