Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
| Заглавие |
Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats
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| Автор |
Sutunkova, M. P.
Minigalieva, I. A. Shelomencev, I. G. Privalova, L. I. Ryabova, Y. V. Tazhigulova, A. V. Amromin, L. A. Minigalieva, R. F. Sutunkova, Y. M. Gurvich, V. B. Makoveeva, E. V. Toropova, L. V. |
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| Тематика |
ADMINISTRATION, INTRANASAL
ANIMALS BRAIN FEMALE MICROSCOPY, ELECTRON NANOPARTICLES OLFACTORY BULB RATS LEAD OXIDE NANOPARTICLE ANIMAL BRAIN CHEMISTRY ELECTRON MICROSCOPY FEMALE INTRANASAL DRUG ADMINISTRATION OLFACTORY BULB RAT |
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| Описание |
White outbred female rats were exposed intranasally to 50-µL of suspension of lead oxide nanoparticles (PbO NPs) at a concentration of 0.5 mg/mL thrice a week during six weeks. A control group of rats was administered deionized water in similar volumes and conditions. The developed intoxication was manifested by altered biochemical and cytochemical parameters, as well as behavioral reactions of animals. Using electron microscopy and energy-dispersive X-ray spectroscopy techniques, we revealed deposition of PbO NPs in the olfactory bulb, but not in basal ganglia, and an increase in the number of axons with damage to the myelin sheath in the tissues of olfactory bulb and basal ganglia, changes in the ultrastructure of mitochondria of neurons in the tissues of olfactory bulb and basal ganglia of the brain, and differences in the mitochondrial profile of neurons in different regions of the rat brain. Our results collectively suggest that the central nervous system may be a target of low-level toxicity of lead oxide nanoparticles. © 2022, The Author(s).
Ural Federal University Program of Development Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers Ministry of Education and Science of the Russian Federation, Minobrnauka The research funding from Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers for funding the experimental materials and facilities is gratefully acknowledged. The research funding from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority–2030 Program) for experiment implementation and analysis of its results is gratefully acknowledged. |
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| Дата |
2024-04-08T11:07:29Z
2024-04-08T11:07:29Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Sutunkova, MP, Minigalieva, IA, Shelomencev, IG, Privalova, LI, Ryabova, YV, Tazhigulova, AV, Amromin, LA, Minigalieva, RF, Sutunkova, YM, Gurvich, VB, Makoveeva, EV & Toropova, LV 2022, 'Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats', Scientific Reports, Том. 12, № 1, 19444. https://doi.org/10.1038/s41598-022-24018-7
Sutunkova, M. P., Minigalieva, I. A., Shelomencev, I. G., Privalova, L. I., Ryabova, Y. V., Tazhigulova, A. V., Amromin, L. A., Minigalieva, R. F., Sutunkova, Y. M., Gurvich, V. B., Makoveeva, E. V., & Toropova, L. V. (2022). Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats. Scientific Reports, 12(1), [19444]. https://doi.org/10.1038/s41598-022-24018-7 2045-2322 Final All Open Access; Gold Open Access; Green Open Access https://www.nature.com/articles/s41598-022-24018-7.pdf https://www.nature.com/articles/s41598-022-24018-7.pdf http://elar.urfu.ru/handle/10995/131470 10.1038/s41598-022-24018-7 85141972679 000883823800070 |
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| Язык |
en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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| Издатель |
Nature Research
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| Источник |
Scientific Reports
Scientific Reports |
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