Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish
Электронный научный архив УРФУ
Информация об архиве | Просмотр оригинала| Поле | Значение | |
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Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish
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| Автор |
Demin, K. A.
Krotova, N. A. Ilyin, N. P. Galstyan, D. S. Kolesnikova, T. O. Strekalova, T. de Abreu, M. S. Petersen, E. V. Zabegalov, K. N. Kalueff, A. V. |
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| Тематика |
ANIMALS
BRAIN DEPRESSIVE DISORDER, MAJOR HUMANS MOOD DISORDERS RATS TRANSCRIPTOME ZEBRAFISH TRANSCRIPTOME ANIMAL BRAIN GENETICS HUMAN MAJOR DEPRESSION MOOD DISORDER RAT ZEBRA FISH |
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| Описание |
Widespread, debilitating and often treatment-resistant, depression and other stress-related neuropsychiatric disorders represent an urgent unmet biomedical and societal problem. Although animal models of these disorders are commonly used to study stress pathogenesis, they are often difficult to translate across species into valuable and meaningful clinically relevant data. To address this problem, here we utilized several cross-species/cross-taxon approaches to identify potential evolutionarily conserved differentially expressed genes and their sets. We also assessed enrichment of these genes for transcription factors DNA-binding sites down- and up- stream from their genetic sequences. For this, we compared our own RNA-seq brain transcriptomic data obtained from chronically stressed rats and zebrafish with publicly available human transcriptomic data for patients with major depression and their respective healthy control groups. Utilizing these data from the three species, we next analyzed their differential gene expression, gene set enrichment and protein–protein interaction networks, combined with validated tools for data pooling. This approach allowed us to identify several key brain proteins (GRIA1, DLG1, CDH1, THRB, PLCG2, NGEF, IKZF1 and FEZF2) as promising, evolutionarily conserved and shared affective ‘hub’ protein targets, as well as to propose a novel gene set that may be used to further study affective pathogenesis. Overall, these approaches may advance cross-species brain transcriptomic analyses, and call for further cross-species studies into putative shared molecular mechanisms of affective pathogenesis. © 2022, The Author(s).
International Stress and Behavior Society International Zebrafish Neuroscience Research Consortium ZNRC Ministry of Education and Science of the Russian Federation, Minobrnauka, (075-15-2022-301) Funding text 1: This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301). AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) and President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior.com) that coordinated this collaborative multi-laboratory project. The consortium provided a collaborative idea exchange platform for this study. It is not considered as affiliation and did not fund the study. The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish. Funding text 2: This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301). AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) and President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior.com ) that coordinated this collaborative multi-laboratory project. The consortium provided a collaborative idea exchange platform for this study. It is not considered as affiliation and did not fund the study. The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish. |
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| Дата |
2024-04-08T11:07:30Z
2024-04-08T11:07:30Z 2022 |
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| Тип |
Article
Journal article (info:eu-repo/semantics/article) Published version (info:eu-repo/semantics/publishedVersion) |
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| Идентификатор |
Demin, KA, Krotova, NA, Ilyin, NP, Galstyan, DS, Kolesnikova, TO, Strekalova, T, de Abreu, MS, Petersen, EV, Zabegalov, KN & Kalueff, AV 2022, 'Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish', Scientific Reports, Том. 12, № 1, 20836. https://doi.org/10.1038/s41598-022-22688-x
Demin, K. A., Krotova, N. A., Ilyin, N. P., Galstyan, D. S., Kolesnikova, T. O., Strekalova, T., de Abreu, M. S., Petersen, E. V., Zabegalov, K. N., & Kalueff, A. V. (2022). Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish. Scientific Reports, 12(1), [20836]. https://doi.org/10.1038/s41598-022-22688-x 2045-2322 Final All Open Access; Gold Open Access; Green Open Access https://www.nature.com/articles/s41598-022-22688-x.pdf https://www.nature.com/articles/s41598-022-22688-x.pdf http://elar.urfu.ru/handle/10995/131472 10.1038/s41598-022-22688-x 85143120972 000932261400004 |
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en
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| Права |
Open access (info:eu-repo/semantics/openAccess)
cc-by https://creativecommons.org/licenses/by/4.0/ |
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| Формат |
application/pdf
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Nature Research
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| Источник |
Scientific Reports
Scientific Reports |
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